We present mid-infrared continuum and emission line images of the Galactic oxygen-rich supernova remnant (SNR) G292.0+1.8, acquired using the MIPS and IRS instruments on the Spitzer Space Telescope. The MIPS 24 μm and 70 μm images of G292.0+1.8 are dominated by continuum emission from a network of filaments encircling the SNR. The morphology of the SNR, as seen in the mid-infrared, resembles that seen in X-rays with the Chandra X-Ray Observatory. Most of the mid-infrared emission in the MIPS images is produced by circumstellar dust heated in the non-radiative shocks around G292.0+1.8, confirming the results of earlier mid-IR observations with AKARI. In addition to emission from hot dust, we have also mapped atomic line emission between 14 μm and 36 μm using IRS spectral maps. The line emission is primarily associated with the bright oxygen-rich optical knots, but is also detected from fast-moving knots of ejecta. We confirm our earlier detection of 15-25 μm emission characteristic of magnesium silicate dust in spectra of the radiatively shocked ejecta. We do not detect silicon line emission from any of the radiatively shocked ejecta in the southeast of the SNR, possibly because the reverse shock has not yet penetrated most of the Si-rich ejecta in that region. This may indicate that G292.0+1.8 is less evolved in the southeast than the rest of the SNR, and may be further evidence in favor of an asymmetric SN explosion as proposed in recent X-ray studies of G292.0+1.8.