2022
DOI: 10.1101/2022.06.15.22276383
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Exploring the lifetime effect of children on wellbeing using two-sample Mendelian randomisation

Abstract: ObjectivesTo provide Mendelian randomisation evidence of the effect of having children on parental wellbeing.DesignTwo sample Mendelian randomisation.SettingNon-clinical European ancestry participants.ParticipantsWe used the UK Biobank (460,654 male and female European ancestry participants) as a source of genotype-exposure associations, and the Social Science Genetics Consortia (SSGAC) (298,420 male and female European ancestry participants) and Within-Family Consortia (effective sample of 22,656 male and fem… Show more

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Cited by 2 publications
(2 citation statements)
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“…Since not all consortia force each study to perform identical GWASs, it could be difficult to compare the methodology to a single study GWAS. However, our applications of this method here and elsewhere to date imply that in practice consortia which use different methods to a single study GWAS, or which do not enforce homogenous methods, do not produce heterogeneous effects from single study GWASs drawn from a comparable population [22][23][24]. We would however suggest, when possible, triangulating our proposed sensitivity analysis with other approaches, such as a comparison of the measured demographic factors.…”
Section: Limitationsmentioning
confidence: 91%
“…Since not all consortia force each study to perform identical GWASs, it could be difficult to compare the methodology to a single study GWAS. However, our applications of this method here and elsewhere to date imply that in practice consortia which use different methods to a single study GWAS, or which do not enforce homogenous methods, do not produce heterogeneous effects from single study GWASs drawn from a comparable population [22][23][24]. We would however suggest, when possible, triangulating our proposed sensitivity analysis with other approaches, such as a comparison of the measured demographic factors.…”
Section: Limitationsmentioning
confidence: 91%
“…Likewise, the gene-environment equivalence assumption, which is required for MR estimates to translate to the effects of pharmacological interventions, is less plausible when using these behavioral phenotypes (52,53). We believe that the two issues we have highlighted here could be relevant for other pharmacological targets.…”
Section: Discussionmentioning
confidence: 97%