2021
DOI: 10.1155/2021/5597586
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Exploring the Mechanism of Scutellaria baicalensis Georgi Efficacy against Oral Squamous Cell Carcinoma Based on Network Pharmacology and Molecular Docking Analysis

Abstract: Background. Scutellaria baicalensis Georgi (SBG) has been widely shown to induce apoptosis and inhibit invasion and migration of various cancer cells. Increased evidence shows that SBG may be useful to treat oral squamous cell carcinoma (OSCC). However, the biological activity and possible mechanisms of SBG in the treatment of OSCC have not been fully elucidated. This study aimed to clarify the bioactive component and multitarget mechanisms of SBG against OSCC using network pharmacology and molecular docking. … Show more

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Cited by 7 publications
(7 citation statements)
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“…This type of analysis provides a powerful tool for exploring the mechanisms of action of traditional Chinese medicines and developing active ingredients of traditional Chinese medicines [ 44 , 45 ]. Network pharmacology is also visually presented through the network structure diagram of “Traditional Chinese Medicine-Ingredients-Targets–Diseases,” which can effectively reveal the key nodes of traditional Chinese medicine compounds [ 46 49 ], predict the potential mechanisms of traditional Chinese medicines, and discover innovative drugs [ 50 ].…”
Section: Discussionmentioning
confidence: 99%
“…This type of analysis provides a powerful tool for exploring the mechanisms of action of traditional Chinese medicines and developing active ingredients of traditional Chinese medicines [ 44 , 45 ]. Network pharmacology is also visually presented through the network structure diagram of “Traditional Chinese Medicine-Ingredients-Targets–Diseases,” which can effectively reveal the key nodes of traditional Chinese medicine compounds [ 46 49 ], predict the potential mechanisms of traditional Chinese medicines, and discover innovative drugs [ 50 ].…”
Section: Discussionmentioning
confidence: 99%
“…Targets related to embryotoxicity were acquired by combining targets from the two databases and deleting duplicates. These co-targets were then filtered using Venny 2.1 ( , accessed on 1 July 2022) and classified as possible targets for H. cordata in embryotoxicity [ 45 ].…”
Section: Methodsmentioning
confidence: 99%
“…The keywords “chronic obstructive pulmonary disease” were used to search the databases GeneCard (https://www.genecards.org/ 22 ), Online Mendelian Inheritance in Man (OMIM) (https://omim.org/), 23 and Therapeutic Target Database (TTD) (http://db.idrblab.net/ttd/ 24 ) to obtain COPD-related targets. Targets with reference scores greater than 30 were selected as candidates, and duplicates were eliminated …”
Section: Methodsmentioning
confidence: 99%