Exploring the Ovarian Reserve Within Health Parameters: A Latent Class Analysis

Hardy, Theresa M.; Garnier‐Villarreal, Mauricio; McCarthy, Donna O.; Anderson, Richard A.; Reynolds, Rebecca M.

doi:10.1177/0193945918792303

Cited by 3 publications

(13 citation statements)

References 55 publications

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“…The current evidence on the association between BMI and serum AMH levels in women without PCOS is inconclusive but trending toward no relationship. Table 1 summarizes this evidence: 8 studies indicate no association, 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 while 2 found a positive association within at least one cohort 18 , 19 and 4 determined an negative relationship within at least one cohort. 20 , 21 , 22 , 23 A 2020 study by Jaswa et al found that AMH serum levels declined significantly with increasing BMI in the population without obesity (BMI <30 kg/m 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…In contrast to the significant correlation denoted above, other studies' explorations have returned no association. Hardy et al was one of such studies that determined no correlation 11 . However, as obesity has a documented negative impact on fertility, the postpartum status of all patients in Hardy et al is to be noted when considering the generalizability of the cohort's reproductive markers 2 .…”

Section: Resultsmentioning

confidence: 99%

“…Hardy et al was one of such studies that determined no correlation. 11 However, as obesity has a documented negative impact on fertility, the postpartum status of all patients in Hardy et al is to be noted when considering the generalizability of the cohort's reproductive markers. 2 The study compared AMH levels between normal‐weight groups and groups with a BMI of at least 40 kg/m 2 ; thus, these results agree with Jaswa et al's findings that a relationship between AMH and BMI does not exist at obese BMIs.…”

Section: Resultsmentioning

confidence: 99%

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The relationship between anti‐Müllerian hormone, body mass index and weight loss: A review of the literature

2022

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Anti-Müllerian hormone (AMH) is commonly used as a proxy for ovarian reserve due to its secretion by antral follicles. It is considered a metric for prediction of ovarian response to certain assisted reproduction therapies. As obesity has a negative impact on fertility, it is important to establish whether obesity-induced hormonal changes influence AMH levels, if and how weight loss affects AMH, and if that influence represents altered reproductive function. The aim of this study was to review the existing literature on the effects of body mass index and weight loss on AMH levels. A PubMed literature keyword search with relevant terms was performed to identify studies that have reported on the AMH/BMI relationship in cohorts with or without polycystic ovarian syndrome (PCOS). A second search was performed to gather publications on weight loss and AMH. Both searches were filtered for all full-text, Englishlanguage, adult-female and human-only literature through 1 January 2022. The relationship between AMH and body mass index (BMI) in reproductive-aged women remains inconclusive, with studies in women with and without PCOS producing mixed results. Research in this area is currently limited by failure to analyse the full spectrum of obesity, hindering generalization to a global population increasingly affected by the condition. Some authors pointed to evidence of race/ethnicity as a confounding factor of the relationship, but results between studies are contradictory.Limited evidence on weight loss suggests it may decrease AMH levels despite improving fertility outcomes, particularly after bariatric surgery. The impact of BMI and weight loss on AMH levels has not been conclusively established. Future studies will require appropriate design and sample size calculations, consideration for additional potential confounding factors and inclusion of higher BMIs and a thorough analysis of the full range of obesity.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The relationship between anti‐Müllerian hormone, body mass index and weight loss: A review of the literature

2022

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“…The characteristics of the articles included in this systematic review are summarized in Table 5 . Six articles were conducted in the USA [ 28 , 29 , 30 , 31 , 32 , 38 ], two in France [ 42 , 44 ], two in China [ 34 , 43 ], and one each in Taiwan [ 21 ], Australia [ 33 ], Scotland [ 41 ], Turkey [ 45 ], the United Arab Emirates [ 40 ], Israel [ 46 ], India [ 35 ], Brazil [ 36 ], Denmark [ 37 ], and the Philippines [ 39 ]. The mean age of the study participants was 32.3 years.…”

Section: Resultsmentioning

confidence: 99%

Assessment of Nutritional Status and Its Influence on Ovarian Reserve: A Systematic Review

Prieto-Huecas,

Piera-Jordán,

Serrano De La Cruz-Delgado

et al. 2023

Nutrients

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Background: Nowadays, there is a growing interest in the relationship among lifestyle, reproductive health, and fertility. Recent investigations highlight the influence of environmental and lifestyle factors such as stress, diet, and nutritional status on reproductive health. The aim of this review was to determine the influence of nutritional status on ovarian reserve in order to improve the reproductive health of women of childbearing age. Methods: A systematic literature review was carried out following the PRISMA method. The quality of the studies was assessed using the Cochrane Collaboration Risk of Bias tool. Data were extracted, and the results were summarized into two blocks: according to the technique used to assess ovarian reserve and nutritional status; according to the results found in the relationship between ovarian reserve and nutritional status. Results: A total of 22 articles involving 5929 women were included. In 12 of the included articles (54.5%), a relationship between nutritional status and ovarian reserve was demonstrated. In seven publications (31.8%), the increased body mass index (BMI) led to a decrease in ovarian reserve, two of them (0.9%) in patients with polycystic ovary syndrome, showing a decrease only if BMI > 25. In two articles (0.9%), there was a negative relationship between ovarian reserve and waist-to-hip ratio, and in one (0.45%), a positive relationship was shown between ovarian reserve and testosterone levels, the latter being related to body mass index. In five articles (22.7%), body mass index was used as a confounder and was negatively related to ovarian reserve, and in another four (18%), no correlation was found. Conclusions: Ovarian reserve appears to be influenced by nutritional status. A high body mass index has a negative impact on the ovary, decreasing antral follicle count and anti-Müllerian hormone. Oocyte quality is compromised, increasing the rate of reproductive problems and the demand for assisted reproductive techniques. Further studies are needed to understand which dietary factors have the greatest effect on ovarian reserve in order to promote reproductive health.

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“…8,9 The common usage of AMH levels as a measure of fertility necessitates understanding its possible relationship with body mass. Some studies in populations without PCOS have indicated there is no relationship, [10][11][12][13][14][15] while others have found an inverse association. [16][17][18][19][20] The same conflicting results have been found in populations with PCOS, with some studies indicating a negative relationship 12,17,[19][20][21][22] and others not.…”

Section: Introductionmentioning

confidence: 99%

Increased body mass index is negatively associated with ovarian reserve as measured by anti‐Müllerian hormone in patients with polycystic ovarian syndrome

Kloos,

Perez,

Weinerman

2023

Clinical Obesity

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SummaryAnti‐Müllerian hormone (AMH) is commonly used as a marker of ovarian reserve. Although obesity is associated with decreased fertility, the relationship between body mass index (BMI) and AMH remains uncertain, hindering the accurate interpretation of AMH. We sought to assess the relationship between serum AMH and BMI in patients with and without polycystic ovarian syndrome (PCOS). This study analysed 500 patients at a single centre between 2020 and 2021. Patients were divided into cohorts: those with BMI <40 kg/m2 and those with BMI >40 kg/m2. Patients with and without PCOS were included. Chi‐square tests, Fisher's exact tests, multiple linear regression analysis and independent t‐tests were performed as appropriate. In the general study population, serum AMH was not significantly different in the BMI >40 kg/m2 group compared to the BMI <40 kg/m2 group (4.3 ± 5.6 vs. 4.3 ± 5.6, p = .35). Patient ages between these two groups differed, with an average age of 35.4 ± 5.4 years in the BMI <40 kg/m2 group and 33.7 ± 5.4 years in the BMI <40 kg/m2 group (p = .031). Our multivariate regression analysis, which adjusted for age, demonstrated a significant interaction effect between BMI and PCOS diagnosis, indicating that the relationship between BMI and AMH is dependent on PCOS status (β = −.03, 95% confidence interval [CI]: −0.05, 0.00, p = .044). In patients without PCOS, we found a non‐significant relationship between AMH and BMI (β = .00, 95% CI −0.01, 0.01, p = .7); however, in patients with PCOS, AMH significantly decreased as BMI increased (β = −.03, 95% CI −0.06, 0.00, p = .034). BMI has an inverse association with AMH levels in patients with PCOS, indicating a need for future research to determine if that interaction represents a clinically significant negative effect on reproductive function.

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Exploring the Ovarian Reserve Within Health Parameters: A Latent Class Analysis

Cited by 3 publications

References 55 publications

The relationship between anti‐Müllerian hormone, body mass index and weight loss: A review of the literature

The relationship between anti‐Müllerian hormone, body mass index and weight loss: A review of the literature

Assessment of Nutritional Status and Its Influence on Ovarian Reserve: A Systematic Review

Increased body mass index is negatively associated with ovarian reserve as measured by anti‐Müllerian hormone in patients with polycystic ovarian syndrome

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