2023
DOI: 10.3390/biomedicines11082153
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Exploring the Pathogenesis and Mechanism-Targeted Treatments of Rosacea: Previous Understanding and Updates

Chengqian Chen,
Peiru Wang,
Linglin Zhang
et al.

Abstract: Rosacea is a chronic inflammatory skin disease characterized by recurrent erythema, flushing, telangiectasia, papules, pustules, and phymatous changes in the central area of the face. Patients with this condition often experience a significant negative impact on their quality of life, self-esteem, and overall well-being. Despite its prevalence, the pathogenesis of rosacea is not yet fully understood. Recent research advances are reshaping our understanding of the underlying mechanisms of rosacea, and treatment… Show more

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Cited by 15 publications
(12 citation statements)
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References 288 publications
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“…Recent evidence has pointed to the role of activated B cells, as testified by high levels of B cell markers in skin biopsies of rosacea patients [47]. Additionally, B lymphocytes are responsible for the production of fibrogenic cytokines, such as IL-6 and transforming growth factor beta (TGFb), implicated in the fibrotic changes in phymatous rosacea [8].…”
Section: Immune Dysregulationmentioning
confidence: 99%
See 2 more Smart Citations
“…Recent evidence has pointed to the role of activated B cells, as testified by high levels of B cell markers in skin biopsies of rosacea patients [47]. Additionally, B lymphocytes are responsible for the production of fibrogenic cytokines, such as IL-6 and transforming growth factor beta (TGFb), implicated in the fibrotic changes in phymatous rosacea [8].…”
Section: Immune Dysregulationmentioning
confidence: 99%
“…Notably, the sebaceous fatty acid profile in patients with rosacea shows a decrease in long-chain saturated fatty acids that leads to skin dryness and hypersensitivity [61]. In this context, sebocytes could contribute to the general inflammatory status by releasing proinflammatory cytokines and adypokines, including IL-6 [8]. Although the pathophysiological link between chronic inflammation and glandular hyperplasia remains elusive, sebaceous gland dysfunction in rosacea might arise from TLR-mediated inflammatory status, changes in the skin microbiome, alteration in neuronal and endocrine factors, and alteration in skin barrier permeability [62].…”
Section: Other Contributors (Sebaceous Glands Skin Barrier Dysfunctio...mentioning
confidence: 99%
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“… 70 An over 14-year follow-up study showed that body mass index positively correlates with the risk for rosacea at least in females (p < 0.0001). 71 Because of the pathogenic role of inflammation in both obesity and rosacea, 29 , 72 , 73 management of one condition can benefit the other one. The links of seborrheic dermatitis and bullous pemphigoid to neurological, metabolic and cardiovascular diseases have also been well documented.…”
Section: Association Of the Skin With Aging-associated Conditionsmentioning
confidence: 99%
“…2 The related symptoms of rosacea seriously affect the psychological state of patients. 3 Despite its prevalence, the precise mechanisms underlying Rosacea remain uncertain, with potential links to immune and neurovascular disorders, 4 it may also be related to solar damage 5 and demodex mites. 6 Environmental triggers are also believed to contribute to Rosacea's development and progression.…”
Section: Introductionmentioning
confidence: 99%