Exploring the pattern and neural correlates of neuropsychological impairment in late-life depression

Sexton, Claire E.; McDermott, Lisa; Kalu, Ukwuori G.; Herrmann, Lucie L.; Bradley, Kevin M.; Allan, Charlotte L.; Masurier, Marisa Le; Mackay, Clare E.; Ebmeier, Klaus P.

doi:10.1017/s0033291711002352

Cited by 95 publications

(90 citation statements)

References 46 publications

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“…After the screening, 908 articles were excluded as they were not related to the defined research question. Ten reports were screened for full-text and two were excluded as they did not analyze any kind of association between symptom severity and executive functioning, leaving a total of 8 included studies, 9,[20][21][22][23][24][25][26] as illustrated in figure 1. A summary of the participants' clinical and sociodemographic characteristics is presented in Tables 1 and 2.…”

Section: ■ Resultsmentioning

confidence: 99%

“…Regarding the characteristics of the reviewed studies, participants were mainly outpatients with MDD (n=557; 84.5%). Sexton et al 21 mainly included remitted patients (n=27), although they also included patients with mild and moderate symptoms (n=9). Alexopoulos et al 9 included 43 remitted patients, although 15 had recurrence during the follow-up period.…”

Section: ■ Resultsmentioning

confidence: 99%

“…Only three studies reported mean age of depression onset, [21][22][23] ranging from 45.4 to 54.51, with a 51.38 years average. Only two studies reported data regarding mean …”

Section: ■ Resultsmentioning

confidence: 99%

“…20,26 Jungwirth et al 25 included a total of 33.3% of patients on antidepressants, 25 while the sample collected by Sexton et al was mainly on antidepressants (92%). 21 In the study by Alexopoulos et al 9 patients completed a continuation (16 weeks) and maintenance nortriptyline treatment during the 2 year prospective study, although 21 patients had placebo during the maintenance treatment. 9 Moreover, five studies also reported mean MMSE score, with values ranging from 27.51 to 29.9 and an average score of 27.86.…”

Section: ■ Discussionmentioning

confidence: 99%

“…Depression severity was assessed with several different scales including the MADRS, the 17 and 24 item version of the Hamilton Depression Rating Scale (HRDS-17 and HRDS-24) and/or the long and short version of the Geriatric Depression Scale (GDS-30 and GDS-15, respectively Finally, regarding the association between depression severity and executive functioning there were also different analysis procedures from the included studies. Four studies performed correlation analysis, [21][22][23][24] two completed regression analysis 20,25 and two used mixed-effects models. 9,26 Moreover, half the studies used the composite score from executive function tests, [21][22][23] while the other half evaluated the association with each sub score.…”

Section: ■ Discussionmentioning

confidence: 99%

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Association between depression severity and executive functioning in late-life depression: a systematic review

Monteiro¹,

Monteiro²,

Candida³

et al. 2016

Medical Express

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OBJECTIVE: Late-life depression is an under-diagnosed and under-treated disease that reduces the well-being of older adults. Executive dysfunction is another critical impairment in elderly depressed individuals which further disrupts their everyday functioning. This systematic review aims to analyze the association between executive function and depression severity in elderly individuals diagnosed with major depressive disorder. METHOD:The studies were retrieved from MEDLINE/PubMed, ISI Web of Knowledge and PsychInfo, after a search strategy combining the terms "depression", "executive function", "neuropsychological assessment", "elderly" and "late life". Study selection, data collection and quality ratings was performed by two independent raters. RESULTS: A total of 1,130 articles were found but only 8 studies met the defined eligibility criteria and evaluated the association between depression severity and executive functioning. Six out of 8 studies found an association between depression severity and executive function, with correlations ranging from small to large (r= -0.15 to -0.53). The included reports had several methodological limitations such as selective data reporting, non-comprehensive executive function assessment and not controlling potential biases. CONCLUSION: Depression severity may be more strongly correlated with a specific set of executive abilities although it also seems to be a broad-based association with executive functioning as a whole. Future high-quality prospective studies are recommended in order to understand the causal relationship between depression severity and executive functioning taking into account possible mediators such as age-related or neurodegenerative cognitive impairment, educational level and other clinic characteristics (e.g. age of onset, medication).

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Section: ■ Resultsmentioning

confidence: 99%

Section: ■ Resultsmentioning

confidence: 99%

“…Only three studies reported mean age of depression onset, [21][22][23] ranging from 45.4 to 54.51, with a 51.38 years average. Only two studies reported data regarding mean …”

Section: ■ Resultsmentioning

confidence: 99%

Section: ■ Discussionmentioning

confidence: 99%

Section: ■ Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Association between depression severity and executive functioning in late-life depression: a systematic review

Monteiro¹,

Monteiro²,

Candida³

et al. 2016

Medical Express

View full text Add to dashboard Cite

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Default mode network modifications in Fabry disease: A resting‐state fMRI study with structural correlations

Cocozza

Pontillo

Quarantelli

et al. 2018

Human Brain Mapping

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Aim of the study was to evaluate the presence of Default Mode Network (DMN) modifications in Fabry Disease (FD), and their possible correlations with structural alterations and neuropsychological scores. Thirty-two FD patients with a genetically confirmed diagnosis of classical FD (12 males, mean age 43.3 ± 12.2) were enrolled, along with 35 healthy controls (HC) of comparable age and sex (14 males, mean age 42.1 ± 14.5). Resting-State fMRI data were analyzed using a seed-based approach, with six different seeds sampling the main hubs of the DMN. Structural modifications were assessed by means of Voxel-Based Morphometry (VBM) and Tract-Based Spatial Statistics analyses. Between-group differences and correlations with neuropsychological variables were probed voxelwise over the whole brain. Possible correlations between FC modifications and global measures of microstructural alteration were also tested in FD patients with a partial correlation analysis. In the FD group, clusters of increased functional connectivity involving both supratentorial and infratentorial regions emerged, partially correlated to the widespread white matter (WM) damage found in these patients. No gray matter volume differences were found at VBM between the two groups. The connectivity between right inferior frontal gyrus and precuneus was significantly correlated with the Corsi block-tapping test results (p = .0001). Widespread DMN changes are present in FD patients that correlate with WM alterations and cognitive performance. Our results confirm the current view of a cerebral involvement in FD patients not simply associated to major cerebrovascular events, but also related to significant and diffuse microstructural and functional changes.

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The Validity of Vascular Depression as a Diagnostic Construct

Taylor

Mohan

Sachdev

2016

Cardiovascular Diseases and Depression

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Exploring the pattern and neural correlates of neuropsychological impairment in late-life depression

Abstract: Executive function and processing speed appear to represent important cognitive deficits in late-life depression, which contribute to deficits in other domains, and are related to reductions in anisotropy in frontal tracts.

Cited by 95 publications

References 46 publications

Association between depression severity and executive functioning in late-life depression: a systematic review

Association between depression severity and executive functioning in late-life depression: a systematic review

Default mode network modifications in Fabry disease: A resting‐state fMRI study with structural correlations

The Validity of Vascular Depression as a Diagnostic Construct

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