Exploring the potential of anti-inflammatory activity of berberine chloride-loaded mesoporous silica nanoparticles in carrageenan-induced rat paw edema model

Rathod, Krushna; Ahmed, Hafiz; Gomte, Shyam Sudhakar; Chougule, Sourav; Prabakaran, A; Dethe, Mithun Rajendra; Patel, Ravish J.; PVP, Deepak Bharadwaj; Alexander, Amit

doi:10.1016/j.jssc.2022.123639

Cited by 27 publications

(4 citation statements)

References 72 publications

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“…The biphasic nature of carrageenan-induced edema makes it a useful model for studying the mechanisms of acute inflammation and evaluating the anti-inflammatory activities of drugs and natural compounds. Broad-spectrum anti-inflammatory compounds exhibit action against both the early and late stages of carrageenan-induced edema ( Rathod et al, 2023 ).…”

Section: Resultsmentioning

confidence: 99%

Exploring the potential of propanamide-sulfonamide based drug conjugates as dual inhibitors of urease and cyclooxygenase-2: biological and their in silico studies

et al. 2023

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Derivative synthesis has been a crucial method for altering the effects of already-approved medications, especially to lessen adverse effects and enhance results. Making use of this multi-target approach, a series of naproxen-sulfa drug conjugates was designed and synthesized. The newly designed conjugates were confirmed by spectroscopic techniques like IR, 1HNMR, 13CNMR, and elemental analysis. The conjugates were screened for anti-inflammatory, urease, and cyclooxygenase-2 (COX-2) inhibition. Naproxen conjugated with sulfanilamide, sulfathiazole, and sulfaguanidine was found potent and showed a competitive mode of urease inhibition, with IC50 (µM) values 6.69 ± 0.11, 5.82 ± 0.28, 5.06 ± 0.29, respectively. When compared to other screened conjugates, the naproxen-sulfamethoxazole conjugation showed better anti-inflammatory action by inhibiting induced edema by 82.8%, which is comparable to the medication indomethacin (86.8% inhibition). Whereas it exhibited 75.4% inhibition of COX-2 at 10 µM concentration which is comparable with the reference drug (celecoxib, 77.1% inhibition). Moreover, the binding modes of competitive inhibitors with the urease and COX-2 receptor were predicted through molecular docking studies and their stability analysis through MD simulations showed that these compounds made stable complexes with the respective targets and there were no conformational changes that occurred during simulation. The obtained results showed that the conjugates of approved therapeutic molecules may lead to the development of novel types of pharmacological agents in the treatment of several pathological disorders where urease and COX-2 enzymes are involved.

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Section: Resultsmentioning

confidence: 99%

Exploring the potential of propanamide-sulfonamide based drug conjugates as dual inhibitors of urease and cyclooxygenase-2: biological and their in silico studies

et al. 2023

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“…The surfactant solution concentration was from 1 × 10 −6 to 1 × 10 −2 mol/dm 3 , and the Ber concentration in the surfactant solutions was equal to 1 × 10 −4 mol/dm 3 . Because Ber is poorly soluble in water, it was introduced into the aqueous solutions in the form of an ethanolic solution, similar to other research [44][45][46]. The concentration of ethanol in the aqueous solution was constant and equal to 1 × 10 −3 mol/dm 3 .…”

Section: Methodsmentioning

confidence: 99%

Thermodynamic Parameters of Berberine with Kolliphor Mixtures Adsorption and Micellization

2023

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The poor solubility of berberine (Ber) in water limits its practical use. Its solubility can be increased, among other ways, by the addition of surfactants. Of the surfactants, Kolliphor® ELP (ELP) and Kolliphor® RH 40 (RH40) can be very useful in this respect. The increase of Ber’s solubility in water in the presence of ELP and RH40 should be reflected in the composition of the surface layers at the water-air interface and the micelles. The determined composition is reflected in the Gibbs energy of interactions of berberine with ELP and RH40 through the water phase and the standard Gibbs free energy, enthalpy, and entropy of adsorption and micellization. These energies were determined from the equations proposed by us, based on the Gibbs surface excess concentration of the Ber mixture with ELP and RH40, the activity of these compounds in the surface layer at the water-air interface and in the micelles obtained by the Hua and Rosen method, and the contributions of Ber, ELP, and RH40 to the reduction in the water surface tension. For this determination, the measurements of the surface tension of the aqueous solution of the Ber mixture with ELP or RH40 and that of the Ber mixture with these two surfactants, as well as the density and conductivity were performed. Moreover, the fluorescence emission spectra for the Ber + surfactant mixtures were recorded.

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“…The prodrug and the active drug were administered 1 h before the carrageenan injection. The paw volume was measured after 1 h, 3 h, 6 h and 8 h. 24 Percentage edema was calculated using the formula: Anti-inflammatory efficacy of DCF-HS in the inflammationinduced acute liver injury model…”

Section: Effect Of the Prodrug Dcf-hs On The Carrageenan-induced Rat ...mentioning

confidence: 99%

Inflammatory-stimuli-responsive turn-on NIR fluorogenic theranostic prodrug: adjuvant delivery of diclofenac and hydrogen sulfide attenuates acute inflammatory disorders

Sufian,

Parihar,

Badirujjaman

et al. 2024

J. Mater. Chem. B

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Exploring the potential of anti-inflammatory activity of berberine chloride-loaded mesoporous silica nanoparticles in carrageenan-induced rat paw edema model

Cited by 27 publications

References 72 publications

Exploring the potential of propanamide-sulfonamide based drug conjugates as dual inhibitors of urease and cyclooxygenase-2: biological and their in silico studies

Exploring the potential of propanamide-sulfonamide based drug conjugates as dual inhibitors of urease and cyclooxygenase-2: biological and their in silico studies

Thermodynamic Parameters of Berberine with Kolliphor Mixtures Adsorption and Micellization

Inflammatory-stimuli-responsive turn-on NIR fluorogenic theranostic prodrug: adjuvant delivery of diclofenac and hydrogen sulfide attenuates acute inflammatory disorders

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