Exploring the potential of ionic liquid-based electrochemical biosensors for real-time biomolecule monitoring in pharmaceutical applications: From lab to life

Thakur, Abhinay; Kumar, Ashish

doi:10.1016/j.rineng.2023.101533

Cited by 19 publications

(1 citation statement)

References 209 publications

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“…Dopamine detection has been performed earlier with sensing methods like surface-enhanced Raman spectroscopy (SERS), fluorescence spectroscopy, and field effect transistors . To make the process simple and easily scalable, and to minimize the involvement of expensive instruments with skilled operators, while maintaining selectivity, sensitivity, and reproducibility, electrochemical sensing is an effective method. − Research on the electrochemical detection of dopamine has been done previously using a number of different materials, including quantum dots, , aptasensors, , molecular imprinted polymers, noble metals, and 3D frameworks . Although most other works cannot achieve the subpicomolar level detection limit, which is critical for early disease diagnosis, and to encourage the facile fabrication procedure, we have used this liquid-exfoliated 2D CoTe 2 material, which facilitates easy scalability of the sensor to cater the large-scale demand.…”

Section: Introductionmentioning

confidence: 99%

Subpicomolar Dopamine Detection Using Two-Dimensional Cobalt Telluride

Chakraborty,

Ipaves,

Campos de Oliveira

et al. 2024

ACS Appl. Eng. Mater.

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To address the challenges associated with ultrasensitive dopamine sensing for regular health monitoring, here we developed a flexible sensor using two-dimensional cobalt telluride (2D CoTe 2 ). The 2D-CoTe 2 -coated glassy carbon electrode sensor shows a limit of detection (LoD) of 0.21 pM measured by differential pulse voltammetry (DPV) in 0.1 M phosphate buffer solution (PBS). The assessment of selectivity, repeatability, and reproducibility has been conducted, to enquire about the efficiency of the sensor. The durability of the sensor has been verified for a duration of one month, demonstrating a minimal loss of 16% after a period of one month. The interaction of the 2D CoTe 2 and dopamine has been investigated thoroughly by chemical fingerprints using Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, and Raman imaging, and the adsorption of dopamine on 2D CoTe 2 has been confirmed by the theoretical calculations calculating the binding energy, differential charge densities, and projected density of states (pDOS). Additionally, a flexible paper-based sensor using 2D CoTe 2 has been successfully fabricated and employed for real-time dopamine detection from artificial sweat, which achieved a LoD of 0.22 pM.

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