Exploring the potential of phenolic and antioxidant compounds in new <scp>Rosaceae</scp> fruits

Razola‐Díaz, María del Carmen; Aznar‐Ramos, María José; Benítez, Guillermo; Gómez‐Caravaca, Ana María; Verardo, Vito

doi:10.1002/jsfa.13255

Cited by 6 publications

(1 citation statement)

References 94 publications

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“…Phenolic compounds, which are secondary metabolites, can be found in various parts of plants such as fruits, skins, roots, and leaves, with their makeup differing between plant species. One of the most important physiological activities of phenolic compounds is the inhibition of free radicals and delay of damage [17]. Phenylpropionic acids, an important class of phenylpropanoids, are naturally occurring organic acids containing C6-C3 units, including cinnamic acids and phenyllactic acids.…”

Section: Metabolite Identification and Pca Analysismentioning

confidence: 99%

Untargeted Metabolomic Profiling of Fructus Chebulae and Fructus Terminaliae Billericae

Song,

Gong

2024

Applied Sciences

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This study aims to identify the differences in metabolites between Fructus Chebulae (FC) and Fructus Terminaliae Billericae (FTB). Untargeted metabolomics was used to analyze differentially expressed metabolites (DEMs) with ultra-performance liquid chromatography–electrospray ionization–tandem mass spectrometry (UPLC-ESI-MS/MS). A grand total of 558 metabolites were detected, with 155 in positive ion mode and 403 in negative ion mode. Further differential analysis yielded 110 and 87 significantly different metabolites, which were mainly polyphenols, flavonoids, terpenoids, and alkaloids. Analysis of KEGG data showed that differentially expressed metabolites (DEMs) in both positive and negative ion modes were found to be enriched in 5 and 18 metabolic pathways, respectively, with metabolic pathways being the most enriched among them. In sum, this study reveals the differential metabolic profiles of FC and FTB and provides support for their further applications in traditional Chinese medicine.

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Section: Metabolite Identification and Pca Analysismentioning

confidence: 99%

Untargeted Metabolomic Profiling of Fructus Chebulae and Fructus Terminaliae Billericae

Song,

Gong

2024

Applied Sciences

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Optimization of green ultrasound-assisted extraction of phenolic compounds from Crataegus laciniata leaves and assessing for antioxidant activity, enzyme inhibition, and UPLC-ESI-MS-MS guided identification of metabolites

Saidene,

Chaher-Bazizi,

Kadi

et al. 2024

Chem. Pap.

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Investigation of Algerian Crataegus monogyna Jacq Phenolic Compounds (Using LC-ESI-MS/MS Analysis, Antioxidant Activity, and Enzyme Inhibition) and Their Potential Implications for Food and Nutraceutical Applications

Goudjil,

Boussekine,

Goudjil

et al. 2024

Antioxidants

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Investigations into the phenolic constituents of the butanolic fraction of Crataegus monogyna were optimized using LC-ESI-MS/MS analysis, identifying and quantifying at least 23 fingerprint phytochemical compounds. The major phenolic compounds were epicatechin (99.916 ± 2.208 mg/g), isoquercetrin (53.31 ± 1.172 mg/g), chlorogenic acid (47.457 ± 1.010 mg/g), quinic acid (37.819 ± 1.406 mg/g), rutin (29.98 ± 0.740 mg/g), hesperidin (5.296 ± 0.177 mg/g, detected for the first time in the C. monogyna species), astragalin (1.774 ± 0.020 mg/g), and nicotiflorin (1.482 ± 0.016 mg/g). The antioxidant properties of the lyophilized butanolic fraction were evaluated using DPPH, GOR, ABTS, CUPRAC, and reducing power assays, all of which demonstrated that there was strong activity. Additionally, the neuroprotective effect was evaluated in vitro, showing a potent inhibitory effect on acetylcholinesterase (AChE) with an IC50 of 43.65 ± 2.10 µg/mL. The antidiabetic effect was investigated through α-amylase inhibition (IC50 = 91.19 ± 0.10 µg/mL), showing high inhibitory activity. In addition, the butanolic extract exhibited significant urease inhibition with an IC50 of 26.36 ± 0.05 µg/mL. These results suggest that Algerian C. monogyna has potential as a therapeutic agent for managing diabetes complications and as a natural source of AChE inhibitors, making it a promising subject for the treatment of urease-related conditions. Its high concentrations of natural antioxidants, such as epicatechin, isoquercetrin, chlorogenic acid, quinic acid, rutin, hesperidin, and astragalin, make it suitable for integration into medicine, pharmaceuticals, cosmetics, and the food sector.

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Exploring the potential of phenolic and antioxidant compounds in new Rosaceae fruits

Cited by 6 publications

References 94 publications

Untargeted Metabolomic Profiling of Fructus Chebulae and Fructus Terminaliae Billericae

Untargeted Metabolomic Profiling of Fructus Chebulae and Fructus Terminaliae Billericae

Optimization of green ultrasound-assisted extraction of phenolic compounds from Crataegus laciniata leaves and assessing for antioxidant activity, enzyme inhibition, and UPLC-ESI-MS-MS guided identification of metabolites

Investigation of Algerian Crataegus monogyna Jacq Phenolic Compounds (Using LC-ESI-MS/MS Analysis, Antioxidant Activity, and Enzyme Inhibition) and Their Potential Implications for Food and Nutraceutical Applications

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