Exploring the Potential of Supercritical Fluid Extraction of Matricaria chamomilla White Ray Florets as a Source of Bioactive (Cosmetic) Ingredients

Abstract

Aromatic and medicinal plants are a great source of useful bioactive compounds for use in cosmetics, drugs, and dietary supplements. This study investigated the potential of using supercritical fluid extracts obtained from Matricaria chamomilla white ray florets, a kind of industrial herbal byproduct, as a source of bioactive cosmetic ingredients. Response surface methodology to optimize the supercritical fluid extraction process by analyzing the impact of pressure and temperature on yield and the main bioactive compound groups were used. High-throughput 96-well plate spectrophotometric methods were used to analyze the extracts for total phenols, flavonoids, tannins, and sugars, as well as their antioxidant capacity. Gas chromatography and liquid chromatography–mass spectrometry was used to determine the phytochemical composition of the extracts. The extracts were also analyzed for antimicrobial activity, cytotoxicity, phototoxicity, and melanin content. Statistical analysis was performed to establish correlations between the extracts and develop models to predict the targeted phytochemical recovery and chemical and biological activities. The results show that the extracts contained a diverse range of phytochemical classes and had cytotoxic, proliferation-reducing, and antimicrobial activities, making them potentially useful in cosmetic formulations. This study provides valuable insights for further research on the uses and mechanisms of action of these extracts.

In Vitro Safety and Efficacy Evaluation of a Juniperus communis Callus Culture Extract and Matricaria recutita Processing Waste Extract Combination as a Cosmetic Ingredient

“…These compounds have been shown to have various beneficial effects on skin health, including antioxidant activity, maintenance of skin barrier function, wound healing, anti-inflammatory properties, and antimicrobial properties. Sugars, including polysaccharides, are notably abundant in both juniper and chamomile extracts [ 8 , 9 , 10 ]. They are rich in uronic acid and have demonstrated noteworthy moisturizing and hydrating properties [ 20 , 21 , 22 ].…”

“…Recent attention has been focused on the application of natural polysaccharides in diverse fields, including wound healing, anti-aging, and skin whitening, owing to their promising outcomes [ 23 , 24 ]. Apigenin 7-O-glucoside, quinic acid, coumarin derivatives, and ferulic acid glucosides are present in the extract combination and originate mainly from the chamomile extract (701), and their health-promoting activities have been described before [ 8 , 9 , 10 , 25 , 26 , 27 , 28 ]. These compounds effectively neutralize free radicals [ 29 ], mitigating oxidative stress and reducing signs of skin aging [ 30 ].…”

“…Ferulic acid also inhibits tyrosinase activity and melanocyte proliferation, making it a common ingredient in skin-lightening cosmetic products [ 40 ]. Coumarin derivatives are known for their antimicrobial and anti-inflammatory properties [ 9 , 11 , 41 ]. Certain derivatives of coumarin have been recognized for their ability to inhibit tyrosinase, indicating their potential use in controlling skin pigmentation [ 42 ].…”

“…During the distillation process of chamomile flowers, waste materials are generated, often referred to as chamomile herb processing waste. This waste stream, typically considered agricultural waste, presents an opportunity for valorization [ 8 , 9 , 10 , 11 ]. The post-distilled biomass still contains bioactive compounds that are available and sustainable for utilization in various industries, including skincare [ 8 , 9 , 10 ].…”

“…This waste stream, typically considered agricultural waste, presents an opportunity for valorization [8][9][10][11]. The post-distilled biomass still contains bioactive compounds that are available and sustainable for utilization in various industries, including skincare [8][9][10].…”