2024
DOI: 10.3892/ol.2024.14546
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Exploring the potential of the TCR repertoire as a tumor biomarker (Review)

An-Li Huang,
Yan-Zhao He,
Yong Yang
et al.

Abstract: T cells play an important role in adaptive immunity. Mature T cells specifically recognize antigens on major histocompatibility complex molecules through T-cell receptors (TCRs). As the TCR repertoire is highly diverse, its analysis is vital in the assessment of T cells. Advances in sequencing technology have provided convenient methods for further investigation of the TCR repertoire. In the present review, the TCR structure and the mechanisms by which TCRs function in tumor recognition are described. In addit… Show more

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