Exploring the potential of thyroid hormones to predict clinical improvements in depressive patients: A machine learning analysis of the real-world based study.

Qiao, Dan; Liu, Huishan; Zhang, Xuemin; Lei, Lei; Sun, Ning; Yang, Chunxia; Li, Gaizhi; Guo, Meng; Zhang, Kerang; Liu, Zhifen

doi:10.1016/j.jad.2021.11.055

Cited by 13 publications

(10 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yang and colleagues' research targeted a similar population, revealing a negative correlation of hair T3 levels with anxiety and depression severity in first-episode patients with major depressive disorder (F-MDD) (43). A recent study found FT4 values within the normal range were associated with the severity of depression and anxiety (12). Though untreated diagnosed hypothyroidism was positively related to depressive symptoms and anxiety, it appeared no significant link existed between these two symptomologies and TPOAb (19).…”

Section: Discussionmentioning

confidence: 99%

“…There is a considerably strong correlation between mood disorders and thyroid function (10,11). Thyroid hormones (TH) are critical not only for brain development, but also for lifelong central nervous system (CNS) function (11)(12)(13). Numerous studies have demonstrated that TH affect depression and anxiety through multiple mechanisms.…”

Section: Introductionmentioning

confidence: 99%

“…Yet Yu and colleagues suggested a bidirectional effect of thyroid function toward anxiety and depression (15). A retrospective study in China suggested thyroid hormones can reflect the clinical outcome of depression and normal-range free thyroxine (FT4) values are associated with the severity of anxiety and depression (12). Ittermann et al found serum thyroid peroxidases antibody (TPOAb) levels to share no apparent correlation with depression and anxiety (19), while van de Van and colleagues suggested TPOAb to be a predictive biomarker for the vulnerability of depression (20).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of Subclinical Hypothyroidism With Anxiety Symptom in Young First-Episode and Drug-Naïve Patients With Major Depressive Disorder

Yang

et al. 2022

Front. Psychiatry

View full text Add to dashboard Cite

BackgroundsSubclinical hypothyroidism (SCH) was reported to be associated with depression; however, its role in coexisting anxiety symptom in young patients with major depressive disorder (MDD) remains unclear. The objective of this study was to explore the relationship between SCH and anxiety symptom in young first-episode and drug-naïve (FEDN) MDD patients.MethodsA total of 520 outpatients diagnosed as FEDN MDD with SCH were recruited in this study. Their socio-demographic, clinical data and thyroid function parameters were collected. The Hamilton Anxiety Rating Scale (HAMA) and the Hamilton Depression Rating Scale (HAMD) were employed to measure the severity of anxiety symptom and depressive symptom, respectively. Based on the HAMA scores, patients who scored ≥ 25 were defined as anxious major depressive disorder (A-MDD) while others as non-anxious major depressive disorder (NA-MDD).ResultsThe prevalence rate of A-MDD was 15.8% in young FEDN MDD patients with comorbid SCH. Moreover, serum thyroid stimulating hormone (TSH) levels were significantly higher in patients with A-MDD compared with those with NA-MDD (p < 0.001). Multivariate binary logistic regression analysis indicated that A-MDD was associated with serum TSH levels with an odds ratio (OR) of 1.602. Serum TSH level of 6.17 mIU/L was the critical value to distinguish A-MDD and NA-MDD, with sensitivity of 0.805 and specificity of 0.539. There were no statistically significant differences between NA-MDD and A-MDD patients in terms of socio-demographic variables, serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidases antibody (TPOAb) and anti-thyroglobulin (TgAb) levels.ConclusionsA-MDD patients presented higher serum TSH level. It is suggested that serum TSH level may be a potential biomarker for predicting moderate and severe anxiety symptoms in young FEDN MDD patients with SCH.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of Subclinical Hypothyroidism With Anxiety Symptom in Young First-Episode and Drug-Naïve Patients With Major Depressive Disorder

Yang

et al. 2022

Front. Psychiatry

View full text Add to dashboard Cite

show abstract

“…Patients with thyroid function disorder exhibit a high prevalence of depression [ 17 , 18 ]. Numerous large sample sized studies with participants from different cultural and ethnic backgrounds have demonstrated correlations between thyroid function, including hyper- and hypoactivity of thyroid function, and depression [ [19] , [20] , [21] ]. Moreover, thyroid hormone (TH)'s effects on depression were confirmed in animal experiments [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Association between thyroid function and psychotic symptoms in adolescents with major depressive disorder: A large sample sized cross-sectional study in China

Yang

Zhu

Yue

et al. 2023

Heliyon

View full text Add to dashboard Cite

“…The pathophysiological mechanism of MDD is closely related to the somatic endocrine metabolic state, and the thyroid gland is one of the glands responsible for metabolism in the body, which secretes thyroid hormones that can affect the body's energy metabolism, cardiovascular function, cerebral neurotransmission, and other physiological processes [11]. It has been shown that the prevalence of MDD is higher in patients with thyroid dysfunction [12,13], and several studies on subjects of different ethnic and cultural backgrounds have shown a correlation between abnormal thyroid function and depression [14,15]. The MDD neuropathological hypothesis states that decreased 5-hydroxytryptamine concentrations in the brain promote thyrotropin-releasing hormone (TRH) release, subsequently, increased thyroid stimulating hormone (TSH) release [16], and that elevated serum TSH concentrations may act on TSH receptors in adipocytes to inhibit lipid hydrolysis, leading to dyslipidemia [17].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and factors associated with thyroid dysfunction in major depressive disorder patients with dyslipidemia

Zhan

Gao

Zeng³

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Major depressive disorder (MDD) is a common psychiatric disorder with a high prevalence of comorbidity with thyroid dysfunction. The aim of this study was to investigate the prevalence and factors influencing the comorbidity of thyroid dysfunction in patients with dyslipidemic MDD who were hospitalized for the first time in a Chinese population. Methods The study incorporated 708 first-time hospitalized MDD patients, all with dyslipidemia. Data collection encompassed socio-demographic information, blood pressure, fasting blood glucose (FBG), lipid, and thyroid hormone levels. Participants were evaluated using the Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Positive Symptom Subscale (PSS). Results The prevalence of thyroid dysfunction in dyslipidemic MDD patients with the first hospitalization was 39.97%. The course of the disease, age at onset, HAMA score, and low-density lipoprotein cholesterol (LDL-C) were risk factors for thyroid dysfunction in dyslipidemic MDD patients. The course of disease, age at onset, HAMA score, HAMD score, FBG, and systolic blood pressure (SBP) levels were observed to significantly influence serum Thyroid Stimulating Hormone (TSH) levels. Conclusions MDD patients with dyslipidemia have a high prevalence of thyroid dysfunction, and the outcome is associated with anxiety, fasting glucose, and lipids. This study provides direction for the prevention and treatment of thyroid dysfunction in patients with dyslipidemic MDD.

show abstract

Exploring the potential of thyroid hormones to predict clinical improvements in depressive patients: A machine learning analysis of the real-world based study.

Cited by 13 publications

References 30 publications

Association of Subclinical Hypothyroidism With Anxiety Symptom in Young First-Episode and Drug-Naïve Patients With Major Depressive Disorder

Association of Subclinical Hypothyroidism With Anxiety Symptom in Young First-Episode and Drug-Naïve Patients With Major Depressive Disorder

Association between thyroid function and psychotic symptoms in adolescents with major depressive disorder: A large sample sized cross-sectional study in China

Prevalence and factors associated with thyroid dysfunction in major depressive disorder patients with dyslipidemia

Contact Info

Product

Resources

About