Exploring the Potentials of Magnetic Nanoscale Material for Different Biomedical Applications: a Review

Shankar, M.V.; Kesavan, Sudha Sri; Biswas, Kunal

doi:10.1007/s12668-023-01137-7

Cited by 2 publications

(1 citation statement)

References 121 publications

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“…Magnetic nanoparticles (MNPs) have emerged as versatile entities with profound implications across various scientific frontiers. Their unique physicochemical properties, including superparamagnetism and high surface area-to-volume ratios, have positioned them as compelling candidates in fields ranging from biomedicine [1,2] to catalysis [3,4]. However, the strategic engineering of their surfaces by means of surface modifying agents (such as amine, diimide, carboxyl, aldehyde, hydroxyl, etc.)…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Surface Functionalization of Magnetic Nanoparticles

Comanescu

2023

Coatings

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In recent years, significant progress has been made in the surface functionalization of magnetic nanoparticles (MNPs), revolutionizing their utility in multimodal imaging, drug delivery, and catalysis. This progression, spanning over the last decade, has unfolded in discernible phases, each marked by distinct advancements and paradigm shifts. In the nascent stage, emphasis was placed on foundational techniques, such as ligand exchange and organic coatings, establishing the groundwork for subsequent innovations. This review navigates through the cutting-edge developments in tailoring MNP surfaces, illuminating their pivotal role in advancing these diverse applications. The exploration encompasses an array of innovative strategies such as organic coatings, inorganic encapsulation, ligand engineering, self-assembly, and bioconjugation, elucidating how each approach impacts or augments MNP performance. Notably, surface-functionalized MNPs exhibit increased efficacy in multimodal imaging, demonstrating improved MRI contrast and targeted imaging. The current review underscores the transformative impact of surface modifications on drug delivery systems, enabling controlled release, targeted therapy, and enhanced biocompatibility. With a comprehensive analysis of characterization techniques and future prospects, this review surveys the dynamic landscape of MNP surface functionalization over the past three years (2021–2023). By dissecting the underlying principles and applications, the review provides not only a retrospective analysis but also a forward-looking perspective on the potential of surface-engineered MNPs in shaping the future of science, technology, and medicine.

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Section: Introductionmentioning

confidence: 99%

Recent Advances in Surface Functionalization of Magnetic Nanoparticles

Comanescu

2023

Coatings

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Biosynthesis of Iron Oxide Nanoparticles by Marine Streptomyces sp. SMGL39 with Antibiofilm Activity: In Vitro and In Silico Study

Attea,

Ghareeb,

Kelany

et al. 2024

Molecules

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One of the major global health threats in the present era is antibiotic resistance. Biosynthesized iron oxide nanoparticles (FeNPs) can combat microbial infections and can be synthesized without harmful chemicals. In the present investigation, 16S rRNA gene sequencing was used to discover Streptomyces sp. SMGL39, an actinomycete isolate utilized to reduce ferrous sulfate heptahydrate (FeSO4.7H2O) to biosynthesize FeNPs, which were then characterized using UV–Vis, XRD, FTIR, and TEM analyses. Furthermore, in our current study, the biosynthesized FeNPs were tested for antimicrobial and antibiofilm characteristics against different Gram-negative, Gram-positive, and fungal strains. Additionally, our work examines the biosynthesized FeNPs’ molecular docking and binding affinity to key enzymes, which contributed to bacterial infection cooperation via quorum sensing (QS) processes. A bright yellow to dark brown color shift indicated the production of FeNPs, which have polydispersed forms with particle sizes ranging from 80 to 180 nm and UV absorbance ranging from 220 to 280 nm. Biosynthesized FeNPs from actinobacteria significantly reduced the microbial growth of Fusarium oxysporum and L. monocytogenes, while they showed weak antimicrobial activity against P. aeruginosa and no activity against E. coli, MRSA, or Aspergillus niger. On the other hand, biosynthesized FeNPs showed strong antibiofilm activity against P. aeruginosa while showing mild and weak activity against B. subtilis and E. coli, respectively. The collaboration of biosynthesized FeNPs and key enzymes for bacterial infection exhibits hydrophobic and/or hydrogen bonding, according to this research. These results show that actinobacteria-biosynthesized FeNPs prevent biofilm development in bacteria.

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Exploring the Potentials of Magnetic Nanoscale Material for Different Biomedical Applications: a Review

Cited by 2 publications

References 121 publications

Recent Advances in Surface Functionalization of Magnetic Nanoparticles

Recent Advances in Surface Functionalization of Magnetic Nanoparticles

Biosynthesis of Iron Oxide Nanoparticles by Marine Streptomyces sp. SMGL39 with Antibiofilm Activity: In Vitro and In Silico Study

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