Exploring the recent developments of alginate silk fibroin material for hydrogel wound dressing: A review

Zahra, Duaa; Shokat, Zeeshan; Ahmad, Azka; Javaid, Anam; Khurshid, Mohsin; Ashfaq, Usman Ali; Nashwan, Abdulqadir J.

doi:10.1016/j.ijbiomac.2023.125989

Cited by 18 publications

(16 citation statements)

References 164 publications

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“…Silk fibroin (SF) is a natural protein-based biopolymer [ 54 , 60 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 ]. Silk fibers are primarily composed of proteins derived from silkworms, namely fibroin, sericin, and 18 different amino acids [ 56 , 113 ].…”

Section: Polymersmentioning

confidence: 99%

“…This self-assembly approach is relatively simple. However, it can be time-consuming [ 104 , 110 ]. Another technique used to induce hydrogel formation is the ultrasonication technique.…”

Section: Polymersmentioning

confidence: 99%

“…The application of ultrasound waves promotes intermolecular interactions of fibers, leading to a structural rearrangement of the protein. This process involves conformational changes from a random coil to a β-sheet, culminating in hydrogel formation [ 104 , 110 , 115 ]. Previous studies have shown that this technique reduced the gelation time of SF from days to minutes, with the formation of hydrogels reported within 15 to 45 s [ 110 , 115 ].…”

Section: Polymersmentioning

confidence: 99%

“…SF possesses excellent biological properties, including outstanding biocompatibility both in vitro and in vivo, and tunable biodegradability, forming non-inflammatory by-products. It also exhibits high tensile strength and robust mechanical properties, along with excellent flexibility, elasticity, and malleability [ 16 , 17 , 54 , 57 , 60 , 104 , 105 , 106 , 107 , 108 , 110 , 112 , 113 , 114 , 116 , 117 , 119 , 120 ]. Moreover, it is naturally abundant, bio-sustainable [ 121 ], and eco-friendly [ 121 , 122 , 123 ].…”

Section: Polymersmentioning

confidence: 99%

“…In addition to addressing biodegradation issues associated with non-biological materials [ 115 ], SF can act as a natural strengthening agent, providing the desired mechanical strength and hardness, instead of relying on synthetic polymers and chemicals [ 106 , 110 , 113 ]. Studies have shown that the addition of small amounts of SF improved the physical and mechanical properties of a collagen scaffold without affecting its biological nature [ 106 ].…”

Section: Polymersmentioning

confidence: 99%

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Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential

Ribeiro,

Simões,

Vitorino

et al. 2024

Gels

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Hydrogels are polymeric materials that possess a set of characteristics meeting various requirements of an ideal wound dressing, making them promising for wound care. These features include, among others, the ability to absorb and retain large amounts of water and the capacity to closely mimic native structures, such as the extracellular matrix, facilitating various cellular processes like proliferation and differentiation. The polymers used in hydrogel formulations exhibit a broad spectrum of properties, allowing them to be classified into two main categories: natural polymers like collagen and chitosan, and synthetic polymers such as polyurethane and polyethylene glycol. This review offers a comprehensive overview and critical analysis of the key polymers that can constitute hydrogels, beginning with a brief contextualization of the polymers. It delves into their function, origin, and chemical structure, highlighting key sources of extraction and obtaining. Additionally, this review encompasses the main intrinsic properties of these polymers and their roles in the wound healing process, accompanied, whenever available, by explanations of the underlying mechanisms of action. It also addresses limitations and describes some studies on the effectiveness of isolated polymers in promoting skin regeneration and wound healing. Subsequently, we briefly discuss some application strategies of hydrogels derived from their intrinsic potential to promote the wound healing process. This can be achieved due to their role in the stimulation of angiogenesis, for example, or through the incorporation of substances like growth factors or drugs, such as antimicrobials, imparting new properties to the hydrogels. In addition to substance incorporation, the potential of hydrogels is also related to their ability to serve as a three-dimensional matrix for cell culture, whether it involves loading cells into the hydrogel or recruiting cells to the wound site, where they proliferate on the scaffold to form new tissue. The latter strategy presupposes the incorporation of biosensors into the hydrogel for real-time monitoring of wound conditions, such as temperature and pH. Future prospects are then ultimately addressed. As far as we are aware, this manuscript represents the first comprehensive approach that brings together and critically analyzes fundamental aspects of both natural and synthetic polymers constituting hydrogels in the context of cutaneous wound healing. It will serve as a foundational point for future studies, aiming to contribute to the development of an effective and environmentally friendly dressing for wounds.

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Section: Polymersmentioning

confidence: 99%

“…This self-assembly approach is relatively simple. However, it can be time-consuming [ 104 , 110 ]. Another technique used to induce hydrogel formation is the ultrasonication technique.…”

Section: Polymersmentioning

confidence: 99%

Section: Polymersmentioning

confidence: 99%

Section: Polymersmentioning

confidence: 99%

Section: Polymersmentioning

confidence: 99%

See 3 more Smart Citations

Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential

Ribeiro,

Simões,

Vitorino

et al. 2024

Gels

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A Hydrogel Dressing Comprised of Silk Fibroin, Ag Nanoparticles, and Reduced Graphene Oxide for NIR Photothermal‐Enhanced Antibacterial Efficiency and Skin Regeneration

Yan,

Xu,

Wang

et al. 2024

Adv Healthcare Materials

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Bacterial infection, inflammation, and excessive oxidative stress are the primary factors that contribute to delayed healing of skin wounds. In this study, a multifunctional wound dressing (SF/Ag@rGO hydrogel) is developed to promote the healing of infected skin wounds by combining the inherent antibacterial activity of Ag nanoparticles (NPs) with near‐infrared (NIR)‐assisted antibacterial therapy. Initially, L‐ascorbic acid is used as a reducing agent and PVP‐K17 as a stabilizer and dispersant, this facilitates the synthesis of reduced graphene oxide loaded with Ag NPs (Ag@rGO). Ag@rGO was then blended with a silk fibroin (SF) solution to form an instantly gelling SF/Ag@rGO hydrogel that exhibits rapid self‐healing, injectability, shape adaptability, NIR responsiveness, antioxidant, high tissue adhesion, and robust mechanical properties. In vitro and in vivo experiments shows that the SF/Ag@rGO hydrogel demonstrates strong antioxidant and photothermal antibacterial capabilities, promoting wound healing through angiogenesis, stimulating collagen generation, alleviating inflammation, antioxidant, and promoting cell proliferation, indicating that the SF/Ag@rGO hydrogel dressing is an ideal candidate for clinical treatment of full‐thickness bacterial‐stained wounds.This article is protected by copyright. All rights reserved

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Prussian Blue‐Assisted NIR Triggered In‐Situ Polymerized Nanocomposite Hydrogel for Wound Repair

Wu,

Zhang,

et al. 2024

ChemBioChem

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Hydrogels are commonly used as wound dressings to help maintain a moist environment around the wound and isolate contaminants, thus promoting healing. For irregular wounds, the slow healing process and even infection may occur due to the inability of dressings to adhere well to the wound. Prussian blue (PB) is a metal‐organic framework (MOF) material with excellent photothermal conversion and superior stability. In this paper, a kind of near‐infrared (NIR) light triggered in‐situ polymerized antimicrobial hydrogel was prepared. The free radical initiator was encapsulated in the hollow PB by a phase change material (PCM) to maintain stability. The raised temperature triggered by NIR induced the release and decomposition of the initiator. The matrix was formed by the cross‐linking of double bonds on modified chitosan. The quaternary amine groups of modified chitosan and the photothermal properties of PB enhanced the antimicrobial properties of the hydrogel. High‐quality wound healing was demonstrated in the whole skin defect model. This study provides a new reference for the preparation of in‐situ polymerized hydrogel dressings for irregular wounds.

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Exploring the recent developments of alginate silk fibroin material for hydrogel wound dressing: A review

Cited by 18 publications

References 164 publications

Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential

Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential

A Hydrogel Dressing Comprised of Silk Fibroin, Ag Nanoparticles, and Reduced Graphene Oxide for NIR Photothermal‐Enhanced Antibacterial Efficiency and Skin Regeneration

Prussian Blue‐Assisted NIR Triggered In‐Situ Polymerized Nanocomposite Hydrogel for Wound Repair

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