Exploring the relation between human papilloma virus and larynx cancer

A, Mariela Torrente; Ojeda, José Manuel

doi:10.1080/00016480601110238

Cited by 23 publications

(22 citation statements)

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“…8,9 Polymerase chain reaction (PCR) studies of these lesions have identified benign HPV DNA at an average rate of 76.2%. 10 To date, most reports have focused on larger, invasive carcinomas, and few studies have explored the role of HPV in the cellular changes that precede malignancy or occur during the early stages of transformation.…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus in early laryngeal carcinoma

et al. 2009

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Section: Introductionmentioning

confidence: 99%

Human papillomavirus in early laryngeal carcinoma

et al. 2009

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“…In contrast to anogenital SCC, the prevalence of HPV in laryngeal SCC varies considerably, from 3 to 60 % [38,39]. Li and co-workers [40] recently published a meta-analysis with 55 studies, addressing HPV prevalence in laryngeal SCC.…”

Section: Important Differences Between Cervical and Head And Neck Silsmentioning

confidence: 99%

Current Views and Perspectives on Classification of Squamous Intraepithelial Lesions of the Head and Neck

Gale

Zidar

Poljak

et al. 2014

Head and Neck Pathol

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The current state in the field of classifying oral and laryngeal precursor lesions, as proposed in the WHO 2005 Blue Book is not ideal. The results of various interobserver studies have shown that the currently used grading systems, with different basic concepts and different terminology, cannot continue to be reliably used in the future. The different etiology of cervical and head and neck precursor lesions requires a classification designed to cater to the specificities of the head and neck region. Trying to harmonize different classifications of the oral and laryngeal precursor lesions, we have proposed four crucial steps to set up a unified classification of squamous intraepithelial lesions (SILs): (a) the classification should contain two grades, low-grade and high-grade lesions and, specifically for the larynx, an additional grade-carcinoma in situ (CIS) which must be separated from high-grade laryngeal SILs; (b) the terminology should be unified; our preference is for the term SIL over squamous intraepithelial neoplasia; (c) all leading morphological criteria for low-and highgrade lesions, as well as for CIS, should be clearly defined; (d) agreement between clinicians and pathologists should be achieved on the most appropriate choice of treatment of different grades of SILs in separate head and neck areas.

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“…The detection of HPV DNA in premalignant lesions shows that HPV infection can be involved in the development of some lesions. Premalignant oral lesions usually develop as a result of several factors, such as tobacco and alcohol, and the synergistic interaction of HPV infection with these factors may play a role in the progression to cancer (Torrente & Ojeda, 2007). However, although HPV has been found in a large proportion of laryngeal cancers, more epidemiological and experimental studies are needed to clarify the role of HPV in laryngeal carcinomas.…”

Section: Hpv In Laryngeal Cancermentioning

confidence: 99%

“…According to the clinical characteristics and natural history of disease, four different forms of laryngeal papillomas exist, namely isolated juvenile papillomatosis, juvenile multiple, adult and adult isolated multiple (Madkan et al 2007;Torrente & Ojeda, 2007). More recently, this nomenclature has been replaced by recurrent respiratory papillomatosis (RRP), which more accurately describes the extent of the disease and its tendency to recur (Muenscher et al, 2008).…”

Section: Hpv In Laryngeal Cancermentioning

confidence: 99%

“…The oral-genital transmission hypothesis is based on the fact that laryngeal papillomatosis and genital warts have the same associated HPV infections (HPV 6 and 11). The area of transition from cuboidal and cylindrical epithelium in the larynx and uterine cervix may favor the occurrence of HPV in this location (Torrente & Ojeda, 2007).…”

Section: Hpv In Laryngeal Cancermentioning

confidence: 99%

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