Exploring the relevance between brain glucose metabolism and functional connectivity in Chinese cognitive dysfunctions’ subjects using integrated resting-state PET/MRI images

Ding, Changchang; Han, Ying; Jiang, Jiehui

doi:10.1109/embc44109.2020.9175841

Cited by 2 publications

(2 citation statements)

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“…Both 18 FDG‐PET and fMRI metrics independently differentiated AD/MCI patients from healthy controls, with posterior DMN regions exhibiting the greatest changes. Similar findings using PET/MRI are reported by both Ding et al 50 . and Scherr et al 52 .…”

Section: Discussionsupporting

confidence: 90%

“…The default mode network is a tightly connected functional brain network important in memory function, studied previously using predominantly fMRI. reported by both Ding et al 50 and Scherr et al 52 Moreover, withinsubject PET/fMRI correlations showed a 17% reduction in AD/MCI patients compared to controls. These findings support prior unimodal studies [65][66][67] and go further to provide evidence for the theory that glucose-mediated CBF regulation and glucose/oxygen coupling deteriorates with AD disease progression.…”

Section: Functional Connectivity Studiesmentioning

confidence: 73%

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The use of positron emission tomography/magnetic resonance imaging in dementia: A literature review

Lorking

Murray

O’Brien

2021

Int J Geriat Psychiatry

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Objectives Positron emission tomography–magnetic resonance imaging (PET/MRI) is an emerging hybrid imaging system in clinical nuclear medicine. Research demonstrates a comparative utility to current unimodal and hybrid methods, including PET‐computed tomography (PET/CT), in several medical subspecialities such as neuroimaging. The aim of this review is to critically evaluate the literature from 2016 to 2021 using PET/MRI for the investigation of patients with mild cognitive impairment or dementia, and discuss the evidence base for widening its application into clinical practice. Methods A comprehensive literature search using the PubMed database was conducted to retrieve studies using PET/MRI in relation to the topics of mild cognitive impairment, dementia, or Alzheimer's disease between January 2016 and January 2021. This search strategy enabled studies on all dementia types to be included in the analysis. Studies were required to have a minimum of 10 human subjects and incorporate simultaneous PET/MRI. Results A total of 116 papers were retrieved, with 39 papers included in the final selection. These were broadly categorised into reviews (12), technical/methodological papers (11) and new data studies (16). For the current review, discussion focused on findings from the new data studies. Conclusions PET/MRI offers additional insight into the underlying anatomical, metabolic and functional changes associated with dementia when compared with unimodal methods and PET/CT, particularly relating to brain regions including the hippocampus and default mode network. Furthermore, the improved diagnostic utility of PET/MRI, as reported by radiologists, offers improved classification of dementia patients, with important implications for clinical management.

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Section: Discussionsupporting

confidence: 90%