Exploring the resources of the genus Viscum for potential therapeutic applications

Song, Changhoon; Wei, Xu-Ya; Qiu, Zi-Dong; Gong, Li; Chen, Ze-Yan; Ma, Ying; Shen, Ye; Zhao, Yujun; Wang, Weihao; Lai, Chang-Jiang-Sheng; Yang, Bin

doi:10.1016/j.jep.2021.114233

Cited by 23 publications

(27 citation statements)

References 161 publications

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“…A total of 140 compounds were found and identified by mass spectroscopy analysis, including primary metabolites (amino acids, peptides, organic acids, nucleosides, etc.) and secondary metabolites (terpenoids, flavonoids, sterols, coumarins, alkaloids, phenolic acids, sterols, fatty acids, and miscellaneous), confirming the results reported in other studies on this plant [ 10 , 11 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ]. These phytochemicals were assigned to different chemical categories: flavonoids (22.14%), amino acids and peptides (20%), terpenoids (17.85%), phenolic acids (7.85%), fatty acids (7.85%), organic acids (4.28%), nucleosides (3.57%), alcohols and esters (3.57%), coumarins (2.14%), alkaloids (2.14%), amines (2.14%), lignals (2.14%), sterols (1.42%), aldehydes and ketones (1.42%), and other.…”

Section: Resultssupporting

confidence: 89%

“…The chemical screening profile of low-molecular-weight metabolites from viscum was tentatively identified through electrospray ionization–quadrupole time-of-flight mass spectrometry (ESI-QTOF-MS) analysis. The mass spectra of the components identified were accomplished by connecting with those of NIST/EPA/NIH, Mass Spectral Library 2.0 database and reviewing the literature [ 46 , 47 , 48 , 49 , 50 , 51 ]. The mass spectrum and the components identified by ESI-QTOF-MS analysis are presented in Figure 1 and Table 1 .…”

Section: Resultsmentioning

confidence: 99%

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Romanian Viscum album L.—Untargeted Low-Molecular Metabolomic Approach to Engineered Viscum–AuNPs Carrier Assembly

Segneanu

Marin

Herea

et al. 2022

Plants

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Viscum is one of the most famous and appreciated medicinal plants in Europe and beyond. The symbiotic relationship with the host tree and various endogenous and ecological aspects are the main factors on which the viscum metabolites’ profiles depend. In addition, European traditional medicine mentions that only in two periods of the year (summer solstice and winter solstice) the therapeutic potential of the plant is at its maximum. Many studies have investigated the phytotherapeutic properties of viscum grown on different species of trees. However, studies on Romanian viscum are relatively few and refer mainly to the antioxidant and antiproliferative activity of mistletoe grown on Acer campestre, Fraxinus excelsior, Populus nigra, Malus domestica, or Robinia pseudoacacia. This study reports the first complete low-molecular-weight metabolite profile of Romanian wild-grown European viscum. A total of 140 metabolites were identified under mass spectra (MS) positive mode from 15 secondary metabolite categories: flavonoids, amino acids and peptides, terpenoids, phenolic acids, fatty acids, organic acids, nucleosides, alcohols and esters, amines, coumarins, alkaloids, lignans, steroids, aldehydes, and miscellaneous. In addition, the biological activity of each class of metabolite is discussed. The development of a simple and selective phyto-engineered AuNPs carrier assembly is reported and an evaluation of the nanocarrier system’s morpho-structure is performed, to capitalize on the beneficial properties of viscum and AuNPs.

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Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Romanian Viscum album L.—Untargeted Low-Molecular Metabolomic Approach to Engineered Viscum–AuNPs Carrier Assembly

Segneanu

Marin

Herea

et al. 2022

Plants

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“…From 1940 and 2014, approximately 55% of antitumoral drugs approved for cancer treatment came from natural resources [3]. As a prominent example, Viscum album L. (white-berry or European mistletoe) is widely studied [4,5], since it presents a great variety of bioactive compounds [5] and an irrefutable therapeutic potential [6].…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Hydrogel Containing Viscum album Extract for Topic and Transdermal Use: Development, Stability and Cytotoxicity Activity

et al. 2021

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Viscum album L. (Santalaceae), also known as European mistletoe, is a semi-parasitic plant that grows on different host trees. Our group recently demonstrated the antitumoral activity of ethanolic V. album extracts in vitro, depending on the dose and the host tree, V. album ssp abietis from Abies alba being the most active extract. The goal of this work focused on the development of a new topical formulation containing V. album extracts, evaluation of in vitro toxicity and ex vivo skin permeation assays. The Poloxamer 407 hydrogel containing 5% of dry (VA_DEH) or aqueous (VA_AEH) extract presented dermal compatible pH and microbiological stability for 180 days. The hydrogels flow curve presented a non-linear relation, characteristic of non-Newtonian fluids, and the mean viscosity for the VA_DEH and VA_AEH was 372.5 ± 7.78 and 331.0 ± 2.83 Pa.s, respectively, being statistically different (Welch’s t test; p < 0.01). Additionally, WST-1 in vitro assays revealed a dose-dependent toxicity for both formulations and VA_DEH presented a higher activity than the VA_AEH. The promising cytotoxic potential of VA_DEH lead to the ex vivo skin permeation assay with 2.73 ± 0.19 µg/cm2 of chlorogenic acid, which permeated at 8 h, showing a transdermal potential. These in vitro results support the idea that VA_DEH is a novel promising candidate for mistletoe therapy. Therefore, further in vivo and pre-clinical experiments should be performed to evaluate the safety and efficacy of this new dermic delivery system.

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“…Triterpene acids such as oleanolic acid, betulinic acid and ursolic acid are reported in this species as well. [52] Biogenic amines such as tyramine, β-phenylethylamine, aminoalkaloids, are also found, among others. [43] Although viscotoxins and lectins are considered the main active compounds in the aqueous extracts, some evidence suggests that the pharmacological effects are due to the synergy of different substances found in the whole extract.…”

Section: Viscum Albummentioning

confidence: 99%

“…The authors mention that chlorogenic acid is a marker of V. album species and a quality indicator. Triterpene acids such as oleanolic acid, betulinic acid and ursolic acid are reported in this species as well [52] . Biogenic amines such as tyramine, β‐phenylethylamine, aminoalkaloids, are also found, among others [43] .…”

Section: Bioactive Compoundsmentioning

confidence: 99%

The Argentine MistletoesLigaria cuneifolia(Ruiz & Pav.) Tiegh (Loranthaceae) andPhoradendron liga(Gillies ex Hook. & Arn.) Eichler (Santalaceae). Thirty Years of Research

Dobrecky

Lucangioli

Wagner

2022

Chemistry & Biodiversity

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Ligaria cuneifolia (Ruiz & Pav.) Tiegh (Loranthaceae) and Phoradendron liga (Gillies ex Hook. & Arn.) Eichler (Santalaceae) are regarded as Argentine mistletoes based on their similarities with the European counterpart, Viscum album L. (Santalaceae). These two species are the most used medicinal plants to treat high blood pressure in the Argentinian population. To provide scientific grounds to their traditional use and therapeutic potential, they were selected as herbal drug candidates. The main findings would support the anti-hypertensive action, the anticholesterolemic and antioxidant features of L. cuneifolia, and immunomodulatory properties for both species. Quercetin-O-glycosides, galloyl glycosides, and proanthocyanidins are present in L. cuneifolia while P. liga shows C-glycosyl flavones and 3-deoxyproanthocyanidins. This review summarizes the phytochemical characterization, medicinal properties and reveals promising results warranting future efforts for further investigation.

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Exploring the resources of the genus Viscum for potential therapeutic applications

Cited by 23 publications

References 161 publications

Romanian Viscum album L.—Untargeted Low-Molecular Metabolomic Approach to Engineered Viscum–AuNPs Carrier Assembly

Romanian Viscum album L.—Untargeted Low-Molecular Metabolomic Approach to Engineered Viscum–AuNPs Carrier Assembly

Thermoresponsive Hydrogel Containing Viscum album Extract for Topic and Transdermal Use: Development, Stability and Cytotoxicity Activity

The Argentine MistletoesLigaria cuneifolia(Ruiz & Pav.) Tiegh (Loranthaceae) andPhoradendron liga(Gillies ex Hook. & Arn.) Eichler (Santalaceae). Thirty Years of Research

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