Exploring the role of a novel postbiotic bile acid: Interplay with gut microbiota, modulation of the farnesoid X receptor, and prospects for clinical translation

Wang, Beibei; Han, Dong; Hu, Xinyue; Chen, Jing; Liu, Yuwei; Wu, Jing

doi:10.1016/j.micres.2024.127865

Microbiological Research

2024

DOI: 10.1016/j.micres.2024.127865

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Exploring the role of a novel postbiotic bile acid: Interplay with gut microbiota, modulation of the farnesoid X receptor, and prospects for clinical translation

Beibei Wang,

Dong Han,

Xinyue Hu

et al.

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Cited by 4 publications

References 140 publications

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Intermittent Fasting Improves Insulin Resistance by Modulating the Gut Microbiota and Bile Acid Metabolism in Diet‐Induced Obesity

Lei,

Liu,

Wang

et al. 2024

Molecular Nutrition Food Res

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ScopeAdipose tissue macrophages (ATMs) are crucial in the pathogenesis of insulin resistance (IR). Intermittent fasting (IF) is an effective intervention for obesity. However, the underlying mechanism by which IF improves IR remains unclear.Methods and resultsMale C57BL/6J mice are fed chow‐diet and high‐fat diet (HFD) for 12 weeks, then is randomized into ad libitum feeding or every other day fasting for 8 weeks. Markers of ATMs and expression of uncoupling protein 1 (UCP‐1) are determined. Gut microbiota and bile acids (BAs) are profiled using 16S rRNA sequencing and targeted metabolomics analysis. Results indicate that IF improves IR in HFD‐induced obesity. IF decreases ATM infiltration, pro‐inflammatory M1 gene expression, and promotes white adipose tissue (WAT) browning by elevating UCP‐1 expression. IF restructures microbiota composition, significantly expanding the abundance of Verrucomicrobia particularly Akkermansia muciniphila, with the decrease of that of Firmicutes. IF increases the level of total BAs and alters the composition of BAs with higher proportion of 12α‐hydroxylated (12α‐OH) BAs. The changes in these BAs are correlated with differential bacteria.ConclusionThe findings indicate that IF improves IR partially mediated by the interplay between restructured gut microbiota and BAs metabolism, which has implications for the dietary management in obesity.

show abstract

Intermittent Fasting Improves Insulin Resistance by Modulating the Gut Microbiota and Bile Acid Metabolism in Diet‐Induced Obesity

Lei,

Liu,

Wang

et al. 2024

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

An insightful comparison of the current neuroimmune mechanism(s) with the thoughts of differential syndromes from traditional Chinese medicine for the treatment of MDD

Xu,

Zhang,

et al. 2025

Brain Behavior and Immunity Integrative

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Alleviation of alcoholic liver injury through composite postbiotics regulation of intestinal flora and promotion of bile acid metabolism

Peng,

Yang,

Hou

et al. 2024

Food Bioscience

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Exploring the role of a novel postbiotic bile acid: Interplay with gut microbiota, modulation of the farnesoid X receptor, and prospects for clinical translation

Cited by 4 publications

References 140 publications

Intermittent Fasting Improves Insulin Resistance by Modulating the Gut Microbiota and Bile Acid Metabolism in Diet‐Induced Obesity

Intermittent Fasting Improves Insulin Resistance by Modulating the Gut Microbiota and Bile Acid Metabolism in Diet‐Induced Obesity

An insightful comparison of the current neuroimmune mechanism(s) with the thoughts of differential syndromes from traditional Chinese medicine for the treatment of MDD

Alleviation of alcoholic liver injury through composite postbiotics regulation of intestinal flora and promotion of bile acid metabolism

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