Exploring the role of circulating proteins in multiple myeloma risk: a Mendelian randomization study
Matthew A. Lee,
Kate L. Burley,
Emma L. Hazelwood
et al.
Abstract:Background
Multiple myeloma (MM) is an incurable blood cancer with unclear aetiology. Proteomics, the high-throughput measurement of circulating proteins, is a valuable tool in exploring mechanisms of disease. We investigated the causal relationship between circulating proteins and MM risk, using two of the largest cohorts with proteomics data to-date.
Methods
We performed bidirectional two-sample Mendelian randomization (MR; forward MR = causal effect estimation of proteins and MM risk; reverse MR = causal … Show more
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