Exploring the Role of Dairy Products In Sleep Quality: From Population Studies to Mechanistic Evaluations

St‐Onge, Marie‐Pierre; Zuraikat, Faris M.; Neilson, Mackenzie

doi:10.1016/j.advnut.2023.01.004

Cited by 4 publications

(1 citation statement)

References 74 publications

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“…Food and active ingredients have received a lot of attention in terms of disease prevention and treatment. Dairy products have long been regarded as natural sleep aids [5] . Goat milk is a great dietary source.…”

Section: Introductionmentioning

confidence: 99%

Goat casein hydrolysates alleviated insomnia in mice via modulating the level of neurotransmitters and the composition of gut microbiota

Mo,

Jing,

et al. 2024

Food Science and Human Wellness

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Insomnia is associated with neurotransmitters and intestinal dysbiosis. Though studies have demonstrated the ameliorative effects of milk hydrolysates on insomnia, the underlying mechanisms require further exploration. In this study, we investigated how papain hydrolysates of goat casein (CPH) and whey protein (WPH) affected mice's sleeplessness. Here, we show that CPH effectively improved the total sleep time in 12 h and restoring neurotransmitters (5-hydroxytryptamine (5-HT), γ-aminobutyric acid (GABA), dopamine (DA), and norepinephrine (NE)) in mice. Further gut microbiota analysis revealed a significant increase in the relative abundance of Helicobacter and Escherichia-Shigella and a decrease in the relative abundance of Lactobacillus in the insomnia model mice (Model). Compared to the Model group, both CPH and WPH significantly increased the relative abundance of Akkermansia and Lactobacillus while lowering the relative abundance of Helicobacter and Escherichia-Shigella. Notably, while diazepam (DZP) increased mouse sleep duration, it also increased the relative abundance of Colidextribacter, Parasutterella, Muribaculaceae, and Prevotella. Additionally, the gene expression and protein expression of GABAA receptor, cAMP-response element binding protein (CREB), and brain-derived neurotrophic factor (BDNF) were upregulated in the hypothalamus. We also discovered a link between intestinal gut microbiota and neurotransmitters. Overall, our results suggest that goat milk hydrolysates, especially CPH, can effectively improve insomnia, providing a theoretical basis for further experimentation and individualized designs.

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Section: Introductionmentioning

confidence: 99%

Goat casein hydrolysates alleviated insomnia in mice via modulating the level of neurotransmitters and the composition of gut microbiota

Mo,

Jing,

et al. 2024

Food Science and Human Wellness

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The association between milk and dairy products intake and insomnia symptoms among Japanese adults in community-based cohort

Sato,

Yokokawa,

Suzuki

et al. 2024

Nutr Health

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Objective: To examine the association between habitual intake of milk and dairy products and insomnia. Design: Cross-sectional study by using cohort study data among 60,633 participants (22,721 men and 37,912 women) aged 20–74 years in eastern Japan. The data of milk and dairy products intake, sleep status and other lifestyle habits were collected by self-administered questionnaires. The question about milk and dairy products included whole milk, low-fat milk, cheese, yogurt, and lactic acid bacteria beverages, and were assessed by frequency (< 1 time/week, 1–2 times/week, 3–6 times/ week, and ≥ 1 time/day). Sleep status was scored with the Athens Insomnia Scale. Results: Logistic regression analysis showed that adjusted odds ratio (OR) and 95% confidence interval (95% CI) for insomnia were statistically significantly lower for whole milk intake > 1 time/day compared to < 1 time/week in all (OR: 0.91; 95% CI: 0.86–0.96; P = 0.001). The similar results were shown for women (OR: 0.90; 95% CI: 0.85–0.97; P = 0.002), not for men. In contrast, the adjusted odds for insomnia were high in the group that had frequencies of 3–6 times/week of lactic acid bacteria beverages compared to <1 time/week (OR: 1.20, 95% CI: 1.11–1.29; P < 0.001 in all; OR: 1.36; 95% CI: 1.19–1.55; P < 0.001 in men; OR: 1.13; 95% CI: 1.03–1.24; P = 0.009 in women). Conclusions: This cross-sectional study of Japanese populations showed a tendency for no insomniacs to consume whole milk more frequently.

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Properties of milk in sleep induction

Ortega,

Jiménez-Ortega,

Martínez García

et al. 2023

Nutr Hosp

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Exploring the Role of Dairy Products In Sleep Quality: From Population Studies to Mechanistic Evaluations

Cited by 4 publications

References 74 publications

Goat casein hydrolysates alleviated insomnia in mice via modulating the level of neurotransmitters and the composition of gut microbiota

Goat casein hydrolysates alleviated insomnia in mice via modulating the level of neurotransmitters and the composition of gut microbiota

The association between milk and dairy products intake and insomnia symptoms among Japanese adults in community-based cohort

Properties of milk in sleep induction

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