Exploring the role of gut microbiota in obesity and PCOS: Current updates and future prospects

Zhang, Hui; Butoyi, Claudette; Yuan, Guoyue; Jia, Jue

doi:10.1016/j.diabres.2023.110781

Cited by 2 publications

(1 citation statement)

References 80 publications

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“…Furthermore, leptin secretion by adipocytes causes ovarian aromatase inhibition, with lower androgen-to-estrogen conversion rate, and also has a negative effect on folliculogenesis [ 3 ]. Finally, gut microbiota alterations have been widely described in obesity, and several studies have described decreased abundance and variability in both lean and overweight PCOS patients, suggesting a possible new therapeutic frontier [ 30 ].…”

Section: Polycystic Ovary Syndrome In Adolescentsmentioning

confidence: 99%

Low-Calorie Ketogenic Diet: Potential Application in the Treatment of Polycystic Ovary Syndrome in Adolescents

Calcaterra,

Cena,

Sottotetti

et al. 2023

Nutrients

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Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Hyperandrogenism, hyperinsulinism and insulin resistance (IR) are the main drivers of clinical, metabolic and reproductive phenotypes of PCOS. In adolescence, the cornerstones of PCOS treatment are lifestyle and dietary interventions. In particular, the quality and quantity of carbohydrates introduced with the diet play a crucial role in the benefits of diet on PCOS. Recently, the ketogenic diet (KD) has attracted significant interest for the treatment of IR and for the control of carbohydrate metabolism, which has proven to be beneficial for several dysmetabolic conditions, including PCOS. The goal of the KD is to induce a fasting-like metabolism with production of chetonic bodies. Ketosis is a good regulator of calorie intake and mimics the starvation effect in the body, leading to body weight control and consequent metabolism. Additionally, during ketogenesis, insulin receptor sensitivity is also promoted. We proposed a broad overview of the available literature regarding KD indications and considered its metabolic benefits useful for improving PCOS management. The reported data support that a low-calorie ketogenic diet (LCKD) plays a positive role as a regulator of control weight, IR, glucose and lipid homeostasis and hormonal profile. Unfortunately, the evidence concerning the benefits of the very LCKD in adolescents with PCOS and excessive body weight is still numerically scarce. Further studies are necessary to understand whether these effects are due to weight loss or to the nutritional characteristics of this diet. Considering the long-term consequences of PCOS, it is crucial to detect the prospects of nutritional interventions to protect fertility, starting in adolescence.

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Section: Polycystic Ovary Syndrome In Adolescentsmentioning

confidence: 99%

Low-Calorie Ketogenic Diet: Potential Application in the Treatment of Polycystic Ovary Syndrome in Adolescents

Calcaterra,

Cena,

Sottotetti

et al. 2023

Nutrients

View full text Add to dashboard Cite

show abstract

Dietary supplements in polycystic ovary syndrome–current evidence

Han,

Hou,

Han

et al. 2024

Front. Endocrinol.

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Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age, and presents a significant challenge to the global population. This review provides comprehensive evidence of interventions, including food and dietary supplements, aimed at reversing PCOS and improving fertility outcomes. Various dietary supplements are known to cause metabolic changes and hormonal regulation and have a potential impact on increasing pregnancy rates. Although some biochemical alterations have been observed, these metabolic changes do not directly reverse the disorder. Moreover, the lack of sufficient evidence does not convince clinicians to standardize dietary supplements as alternatives to medical or pharmacological interventions. This calls for a study of women with PCOS taking dietary supplements. In addition, unbiased studies of combinations of treatment options for supplements, including large cohort clinical trials, will lead to evidence-based medicine.

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Exploring the role of gut microbiota in obesity and PCOS: Current updates and future prospects

Cited by 2 publications

References 80 publications

Low-Calorie Ketogenic Diet: Potential Application in the Treatment of Polycystic Ovary Syndrome in Adolescents

Low-Calorie Ketogenic Diet: Potential Application in the Treatment of Polycystic Ovary Syndrome in Adolescents

Dietary supplements in polycystic ovary syndrome–current evidence

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