Comprehensive social development requires the coordinated cooperation of various actors in society. The university, as a transformative institution of knowledge, must integrate strategies that contribute to well-being. In Latin American universities, gaps still persist in the implementation of programs that foster entrepreneurship and social innovation, as well as in the adoption of active learning methodologies. The objective of this research is to demonstrate the importance of participating in innovation programs and collaborating with external entities to achieve a positive impact on society. The proposed methodology is based on collaborative learning strategies, collaboration with actors, design thinking, and challenge-based learning focused on social issues. A feedback survey was applied to the students to measure their opinion on the program, soft skills, and social commitment; these data were analyzed through the Jamovi 2.3 program. The results indicated an 80% satisfaction rate. This experience could serve as a precedent for the implementation of similar programs. Furthermore, the students involved in the study demonstrated a strong willingness to continue participating in innovation initiatives aimed at addressing social challenges, contributing significantly to the social dimension of sustainability.