Exploring the Role of Mitochondrial Hydrogen Sulfide in Maintaining Polarity and mtDNA Integrity with a Multichannel Fluorescent Probe

Mu, Shuai; Han, Taihe; Zhang, Xiaoyun; Liu, Jia; Sun, Huipeng; Zhang, Jinlong; Liu, Xiaoyan; Zhang, Haixia

doi:10.1021/acs.analchem.3c03663

Anal. Chem.

2023

DOI: 10.1021/acs.analchem.3c03663

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Exploring the Role of Mitochondrial Hydrogen Sulfide in Maintaining Polarity and mtDNA Integrity with a Multichannel Fluorescent Probe

Shuai Mu,

Taihe Han,

Xiaoyun Zhang

et al.

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Cited by 11 publications

References 35 publications

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Off–On fluorescent benzothiazole‐fused coumarin for sensitive detection of nitroreductases and hydrogen sulfide

Yoo,

Kim,

Lee

2024

Bulletin Korean Chem Soc

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Hydrogen sulfide (H2S) and nitroreductases (NTR) are key biological reductants, with H2S acting as a key signaling molecule and NTR reducing nitro groups to amines in cellular metabolism. Visualizing these reducing components, often overexpressed in cancer cells or bacterial environments, is crucial for metabolic understanding. Existing fluorescent probes detect these individually, but simultaneous detection methods are unexplored. We designed probe 1, which shows high fluorescence only when both NTR and H2S are overexpressed. The probe transformed into benzothiazole‐fused coumarin by NTR, exhibiting fluorescence, and shows a stronger signal in the presence of both NTR and H2S, making it a potential tool for detecting their simultaneous overexpression.

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Off–On fluorescent benzothiazole‐fused coumarin for sensitive detection of nitroreductases and hydrogen sulfide

Yoo,

Kim,

Lee

2024

Bulletin Korean Chem Soc

View full text Add to dashboard Cite

show abstract

An AIE-TICT fluorescence probe cascade responsive to H2S, polarity and viscosity to track microenvironment changes in cellular model of ischemia-reperfusion injury

Ji,

Fu,

Zhang

et al. 2025

Analytica Chimica Acta

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An antioxidative-enhanced endoplasmic reticulum-targeted cyanine dye for efficient tumor immunotherapy

Yang,

Li,

Jin

et al. 2024

Chemical Engineering Journal

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Exploring the Role of Mitochondrial Hydrogen Sulfide in Maintaining Polarity and mtDNA Integrity with a Multichannel Fluorescent Probe

Cited by 11 publications

References 35 publications

Off–On fluorescent benzothiazole‐fused coumarin for sensitive detection of nitroreductases and hydrogen sulfide

Off–On fluorescent benzothiazole‐fused coumarin for sensitive detection of nitroreductases and hydrogen sulfide

An AIE-TICT fluorescence probe cascade responsive to H2S, polarity and viscosity to track microenvironment changes in cellular model of ischemia-reperfusion injury

An antioxidative-enhanced endoplasmic reticulum-targeted cyanine dye for efficient tumor immunotherapy

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