Exploring the role of pericardial miRNAs and exosomes in modulating cardiac fibrosis

Schoettler, Friederike I.; Fatehi Hassanabad, Ali; Jadli, Anshul S.; Patel, Vaibhav B.; Fedak, Paul W.M.

doi:10.1016/j.carpath.2024.107671

Cardiovascular Pathology

2024

DOI: 10.1016/j.carpath.2024.107671

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Exploring the role of pericardial miRNAs and exosomes in modulating cardiac fibrosis

Friederike I. Schoettler,

Ali Fatehi Hassanabad,

Anshul S. Jadli

et al.

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2024

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Cited by 2 publications

References 170 publications

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The immune regulatory role of exosomal miRNAs and their clinical application potential in heart failure

Guo,

Yan,

Yang

et al. 2024

Front. Immunol.

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Heart failure (HF) is a complex and debilitating condition characterized by the heart’s inability to pump blood effectively, leading to significant morbidity and mortality. The abnormality of immune response is a key factor in the progression of HF, contributing to adverse cardiac remodeling and dysfunction. Exosomal microRNAs (miRNAs) play a pivotal role in regulating gene expression and cellular function, which are integral to the crosstalk between cardiac and immune cells, influencing immune cell functions, such as macrophage polarization, T cell activity, and cytokine production, thereby modulating various pathological processes of HF, such as inflammation, fibrosis, and cardiac dysfunction. This review emphasizes the immune-regulatory role of exosomal miRNAs in HF and highlights their clinical potential as diagnostic biomarkers and therapeutic agents.

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The immune regulatory role of exosomal miRNAs and their clinical application potential in heart failure

Guo,

Yan,

Yang

et al. 2024

Front. Immunol.

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Pericardial Fluid Accumulates microRNAs That Regulate Heart Fibrosis after Myocardial Infarction

Silva,

Pereira-Sousa,

Ribeiro-Costa

et al. 2024

IJMS

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Pericardial fluid (PF) has been suggested as a reservoir of molecular targets that can be modulated for efficient repair after myocardial infarction (MI). Here, we set out to address the content of this biofluid after MI, namely in terms of microRNAs (miRs) that are important modulators of the cardiac pathological response. PF was collected during coronary artery bypass grafting (CABG) from two MI cohorts, patients with non-ST-segment elevation MI (NSTEMI) and patients with ST-segment elevation MI (STEMI), and a control group composed of patients with stable angina and without previous history of MI. The PF miR content was analyzed by small RNA sequencing, and its biological effect was assessed on human cardiac fibroblasts. PF accumulates fibrotic and inflammatory molecules in STEMI patients, namely causing the soluble suppression of tumorigenicity 2 (ST-2), which inversely correlates with the left ventricle ejection fraction. Although the PF of the three patient groups induce similar levels of fibroblast-to-myofibroblast activation in vitro, RNA sequencing revealed that PF from STEMI patients is particularly enriched not only in pro-fibrotic miRs but also anti-fibrotic miRs. Among those, miR-22-3p was herein found to inhibit TGF-β-induced human cardiac fibroblast activation in vitro. PF constitutes an attractive source for screening diagnostic/prognostic miRs and for unveiling novel therapeutic targets in cardiac fibrosis.

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Exploring the role of pericardial miRNAs and exosomes in modulating cardiac fibrosis

Cited by 2 publications

References 170 publications

The immune regulatory role of exosomal miRNAs and their clinical application potential in heart failure

The immune regulatory role of exosomal miRNAs and their clinical application potential in heart failure

Pericardial Fluid Accumulates microRNAs That Regulate Heart Fibrosis after Myocardial Infarction

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