“…Focusing on the Axios River, very few scholars are identified to have worked on the thematic of water resources and climate change, e.g., Kapetas et al [64] evaluated the way that climate change (use of CMIP5 climate model under the RCP4.5 scenario), by altering the river flow and precipitation patterns, could affect the coastal aquifers of the Axios basin in terms of salinization, or Poulos et al [65] assessed the consequences of future sea-level rise (by using two customed scenarios of 1.0 and 0.5 m of sea-level rise) on the coastal plain of the Axios River. At the upstream part of the Axios River in North Macedonia (aka the Vardar River) there exists relevant literature; exceptions are Monevska [66], demonstrating precipitation and runoff decreases of 13.0% and 18.8%, respectively, by 2100 based on averaged ensemble values from four General Circulation Models (CSIRO/Mk2, HadCM3, ECHAM4/OPYC3, NCAR-PCM) scaled to six emission scenarios (SRES A1T, A1Fl, A1B, A2, B1, and B2) and Granados et al [67], where the averaged values of the utilized Water Availability and Adaptation Policy Analysis (WAAPA) model triggered by eight model runs for the A2 scenario, four model runs for the B2 scenario, three model runs for the A1B scenario, and five model runs for each RCP-2, RCP-4, RCP-6 and RCP-8 scenario, demonstrated a decrease in the Vardar/Axios's river runoff of 23.0%. For the Kalamas River, despite its importance at regional scale, apart from the Regional Adaptation Action Plans to climate change [68] where a vulnerability analysis for various environmental sectors, economic, and social activities is conducted, no relevant scientific publications were identified.…”