Exploring the role of the combination of propolis and vitamin D3 on VCAM-1 and Caspase-3 expression in preventing atherosclerosis in chronic kidney disease rats

Ismail, Darmawan; Purwanto, Bambang; Wasita, Brian; Supomo, Supomo; Yasa, Ketut Putu; Soetrisno, -

doi:10.15562/bmj.v11i1.3194

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…The polarization and accumulation of macrophages in a chronic pro-inflammatory state can lead to significant and irreversible vascular damage, affecting clinical outcomes [23]. Targeting macrophage inflammation may offer therapeutic potential by promoting early resolution of inflammation [24]. However, the mechanisms underlying macrophage-mediated control of the inflammatory response in the vasculature are not fully understood.…”

Section: Hypoxiamentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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Background:The utilization and advancement of hyperbaric science continue to evolve, encompassing the investigation of cardiovascular disease. Macrophage activation stimulates the expression of matrix metalloproteinases, specifically MMP-12, which play a crucial role in atherosclerosis by influencing vascular tissue. Methods: This study aimed to examine MMP-12 expression in cardiovascular disease induced by an atherogenic high-fat diet and explore the effects of hyperbaric oxygen therapy. Previous research has focused on the primary mechanism of hyperbaric oxygen therapy through the SIRT1 (Sirtuin) pathway, which addresses endothelial dysfunction in atherosclerosis treatment. However, the impact of HBO utilization on the treatment and prevention of cardiovascular disease remains unexplored. Results: Molecular analysis of MMP-12 was conducted using a rat model administered a high-fat diet, followed by HBO treatment. Endothelial dysfunction caused by the high-fat diet was identified as a marker of cardiovascular disease, assessed by endothelin-1 (ET-1) levels. The administration of hyperbaric oxygen (HBO) yielded significant improvements in atherosclerosis and heart disease. The results, with a pvalue of 0.05, were significant for both the treatment and prevention of atherosclerotic heart disease in the two groups used as models. Conclusion: Sprague Dawley rats subjected to hyperbaric oxygen therapy at a pressure of 2.4 ATA, three sessions of 30 minutes each, for ten consecutive days, demonstrated potential for application in cardiovascular disease prevention and treatment.

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Section: Hypoxiamentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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“…Propolis has also demonstrated anti-inflammatory, immunomodulatory, antihypertensive, and antiatherosclerotic activities. Moreover, its constituents possess medicinal properties that enable tissue regeneration and repair after damage [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of propolis hepatotoxicity in male rats

SamieeRad,

Sofiabadi,

Bahadoran

et al. 2024

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Background: Propolis is a natural resinous combination that honeybees produce from the materials they gather from plant parts, buds, and exudates. Numerous favorable pharmacological qualities have been demonstrated for propolis. Objectives: This study aimed to investigate the hepatotoxic effects of ethanolic propolis extract on the liver of male rats. Methods: In this research, 40 male rats were divided randomly into five groups: 1. Control 2. Sham (solvent), and 3. Three experimental groups (ethanolic propolis extract at doses of 50,100 and 200 mg/kg). All materials were administered by oral gavage once daily for 13 consecutive days. On the 14th day, blood sampling was performed to measure serum levels of liver function enzymes and triglycerides. After deep induction of anesthesia, the liver of the rats was removed for histopathological studies. Data were analyzed using ANOVA and Tukey’s test (p <0.05). Results: The data showed that the administration of propolis significantly increased the serum levels of aminotransferases in a dose-dependent manner and decreased triglycerides, accompanied by pathological changes. Conclusions: The results of this study indicate that the administration of propolis is associated with liver toxicity, and it seems that it should be consumed more carefully. Keywords: Alanine aminotransferase, Aspartate aminotransferase, Propolis, Hepatotoxicity Triglycerides

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“…In the elderly population, it is suspected that there is an increase in the activation of the inflammatory system. [2][3][4] Vitamin D is widely known for its function in calcium homeostasis and bone formation. It also plays a role in the inflammatory process and the immune system, which affects the formation and development of atherosclerotic plaques.…”

Section: Introductionmentioning

confidence: 99%

The relationship between inflammatory markers and vitamin D levels with the severity of coronary artery disease in elderly patients

et al. 2022

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Introduction: Coronary artery disease (CAD) is the accumulation of atherosclerotic plaques in the coronary arteries. CAD is the most common cause of death worldwide, and its prevalence continues to increase, especially in the elderly population. Atherosclerosis is a chronic inflammatory condition that involves various inflammatory markers, including tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). In the inflammatory process, vitamin D plays an essential role in developing atherosclerotic plaques affecting the severity of CAD. The elderly are susceptible to vitamin D deficiency and an increase in the inflammatory process related to the severity of CAD. Therefore, this study aims to prove the relationship between inflammatory markers and vitamin D levels with the severity of CAD in elderly patients. Methods: This study used a cross-sectional design in stable CAD patients aged 60 - 75 years who had passed through coronary arteriography. The severity was assessed from the angiography results using the Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) score, which 3 cardiovascular consultants evaluated and the average outcome was calculated. TNF-α, IL-6, and vitamin D were taken during angiography and examined using high sensitivity enzyme-linked immunoabsorbent assay (ELISA). The correlation test was analyzed using Spearman's Rank correlation test. Results: A total of 38 subjects were included in this study, where 30 (78.9%) patients were male. The mean age of the patients was 64.79 years, and the prevalence of vitamin D deficiency was 57.9%. There was a moderately significant positive correlation between markers of inflammation TNF-α (r=0.499, p=0.001) and IL-6 (r=0.518, p=0.001) and the SYNTAX score. A weak negative correlation was also discovered between vitamin D and the SYNTAX score (r=-0.335, p=0.040). Conclusion: The levels of inflammatory markers (TNF-α and IL-6) and vitamin D correlated with the severity of CAD in elderly patients.

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Exploring the role of the combination of propolis and vitamin D3 on VCAM-1 and Caspase-3 expression in preventing atherosclerosis in chronic kidney disease rats

Cited by 4 publications

References 30 publications

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Evaluation of propolis hepatotoxicity in male rats

The relationship between inflammatory markers and vitamin D levels with the severity of coronary artery disease in elderly patients

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