Exploring the <scp>serotonin‐probiotics‐gut</scp> health axis: A review of current evidence and potential mechanisms

Akram, Noor; Faisal, Zargham; Irfan, Rushba; Shah, Yasir Abbas; Batool, Syeda Ayesha; Zahid, Toobaa; Zulfiqar, Aqsa; Fatima, Areeja; Jahan, Qudsia; Tariq, Hira; Saeed, Farhan; Ahmed, Aftab; Asghar, Aasma; Ateeq, Huda; Afzaal, Muhammad; Khan, Mahbubur Rahman

doi:10.1002/fsn3.3826

Cited by 22 publications

(2 citation statements)

References 98 publications

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“…Serotonin, predominantly synthesized by enterochromaffin cells (ECCs), regulates intestinal reflexes, mediates gut-brain communication, and affects the immune system [51,52]. Certain gut microbes can directly produce serotonin, influencing its levels and activity, which in turn impacts gut microbiota composition [53,54]. Similarly, dopamine and norepinephrine, synthesized by both gut microbes and the CNS, have a role in gut-brain communication [53].…”

Section: Paenalcaligenes Hominismentioning

confidence: 99%

The Emerging Role of Human Gut Bacteria Extracellular Vesicles in Mental Disorders and Developing New Pharmaceuticals

Louka,

Koumandou

2024

CIMB

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In recent years, further evidence has emerged regarding the involvement of extracellular vesicles in various human physiopathological conditions such as Alzheimer’s disease, Parkinson’s disease, irritable bowel syndrome, and mental disorders. The biogenesis and cargo of such vesicles may reveal their impact on human health nd disease and set the underpinnings for the development of novel chemical compounds and pharmaceuticals. In this review, we examine the link between bacteria-derived exosomes in the gastrointestinal tract and mental disorders, such as depression and anxiety disorders. Crucially, we focus on whether changes in the gut environment affect the human mental state or the other way around. Furthermore, the possibility of handling bacteria-derived exosomes as vectors of chemicals to treat such conditions is examined.

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Section: Paenalcaligenes Hominismentioning

confidence: 99%

The Emerging Role of Human Gut Bacteria Extracellular Vesicles in Mental Disorders and Developing New Pharmaceuticals

Louka,

Koumandou

2024

CIMB

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“…Microbes in the gut are crucial for managing digestive and immune activities, impacting how various foods, nutrients, metabolites, and drugs are processed and metabolized. − The equilibrium of gut microbes has attracted considerable attention due to its significant impact on human health. Imbalances in gut bacteria have been associated with numerous human ailments, such as digestive, brain, metabolic, lung, and heart diseases .…”

Section: The Interaction Between Gut Bacteria and The Brain In Pdmentioning

confidence: 99%

Pesticides and the Gut Microbiota: Implications for Parkinson’s Disease

Ghosh,

Sinha,

Sil

2024

Chem. Res. Toxicol.

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Parkinson’s disease (PD) affects more people worldwide than just aging alone can explain. This is likely due to environmental influences, genetic makeup, and changes in daily habits. The disease develops in a complex way, with movement problems caused by Lewy bodies and the loss of dopamine-producing neurons. Some research suggests Lewy bodies might start in the gut, hinting at a connection between these structures and gut health in PD patients. These patients often have different gut bacteria and metabolites. Pesticides are known to increase the risk of PD, with evidence showing they harm more than just dopamine neurons. Long-term exposure to pesticides in food might affect the gut barrier, gut bacteria, and the blood–brain barrier, but the exact link is still unknown. This review looks at how pesticides and gut bacteria separately influence PD development and progression, highlighting the harmful effects of pesticides and changes in gut bacteria. We have examined the interaction between pesticides and gut bacteria in PD patients, summarizing how pesticides cause imbalances in gut bacteria, the resulting changes, and their overall effects on the PD prognosis.

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The potential protective effects of probiotics, prebiotics, or yogurt on chronic obstructive pulmonary disease: Results from NHANES 2007–2012

Hong,

Luo

2024

Food Science & Nutrition

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Chronic obstructive pulmonary disease (COPD) ranks among the world's three leading causes of mortality, owing to the increased smokers and aging populations. Previous studies showed that gut microbiota could help to ameliorate respiratory diseases. Hence, the current study aims to evaluate the effects of probiotics, prebiotics, or yogurt on the prevalence of COPD. A cross‐sectional study was carried out by investigating data from three consecutive NHANES cycles during 2007–2012. Individuals who met the inclusion and exclusion criteria were studied. Prescription medications and dietary were reviewed to identify the intake of probiotics, prebiotics, or yogurt. The included participants were then divided into two groups depending on their consumption of probiotics, prebiotics, or yogurt. Multivariate logistic regression analysis was conducted to analyze the effects of probiotics, prebiotics, or yogurt consumption on the prevalence of COPD. Out of 7486 enrolled participants, 1656 (22.12%) were categorized into the probiotics, prebiotics, or yogurt intake group. This study indicated that consuming probiotics, prebiotics, or yogurt were correlated with a lower incidence of COPD, even when factors like gender, age, education, moderate‐intensity activities, vigorous activities, hypertension, asthma, diabetes, smoking and alcohol consumption were accounted for (Model 1: OR, 0.68, 95% CI, 0.53–0.87; Model 2: OR, 0.77, 95% CI, 0.59–0.99; Model 3: OR, 0.75, 95% CI, 0.57–0.98). The findings reveal that consuming probiotics, prebiotics, or yogurt might play a beneficial role in preventing COPD.

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Exploring the serotonin‐probiotics‐gut health axis: A review of current evidence and potential mechanisms

Cited by 22 publications

References 98 publications

The Emerging Role of Human Gut Bacteria Extracellular Vesicles in Mental Disorders and Developing New Pharmaceuticals

The Emerging Role of Human Gut Bacteria Extracellular Vesicles in Mental Disorders and Developing New Pharmaceuticals

Pesticides and the Gut Microbiota: Implications for Parkinson’s Disease

The potential protective effects of probiotics, prebiotics, or yogurt on chronic obstructive pulmonary disease: Results from NHANES 2007–2012

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