A methodology for determining the cyclic variability in spark-ignition (SI) engines has been developed recently, with the use of an in-house computational fluid dynamics (CFD) code. The simulation of a large number of engine cycles is required for the coefficient of variation (COV) of the indicated mean effective pressure (IMEP) to converge, usually more than 50 cycles. This is valid for any CFD methodology applied for this kind of simulation activity. In order to reduce the total computational time, but without reducing the accuracy of the calculations, the methodology is expanded here by simulating just five representative cycles and calculating their main parameters of concern, such as the IMEP, peak pressure, and NO and CO emissions. A regression analysis then follows for producing fitted correlations for each parameter as a function of the key variable that affects cyclic variability as has been identified by the authors so far, namely, the relative location of the local turbulent eddy with the spark plug. The application of these fitted correlations for a large number of engine cycles then leads to a fast estimation of the key parameters. This methodology is applied here for a methane-fueled SI engine, while future activities will examine cyclic variations in SI engines when fueled with different fuels and their mixtures, such as methane/hydrogen blends, and their associated pollutant emissions.