Exploring the structure-activity relationships of diphenylurea as an antibacterial scaffold active against methicillin- and vancomycin-resistant Staphylococcus aureus

Vancomycin as an Antibacterial Agent Capped with Silver Nanoparticles: An Experimental Potential Analysis

“…As more bacterial infections develop multidrug resistance (MDR), the availability of antibiotics has been a critical issue for the healthcare professionals [ 1 ]. The most difficult issues for leading experts in the field of biomedicine are the rise in multiple-drug resistant confined of Pseudomonas aeruginosa, Staphylococcus aureus , Klebsiella pneumoniae, Escherichia coli , Enterococcus faecium, and Enterobacter species to the numerous traditional antibiotics.…”

Expanding the structure–activity relationships of alkynyl diphenylurea scaffold as promising antibacterial agents

“…40 It was determined using the viable count method as previously described. 41,42 Briefly, MRSA USA300 culture was adjusted to an inoculum of ∼10 6 CFU mL −1 and then exposed to 5× MIC of compound 18 or vancomycin for 2 h. A culture containing DMSO was included as a negative control and viable count was determined after the two hours for all the included tests. Afterwards, compound 18, vancomycin, and DMSO were removed by diluting each tube 1 : 1000 in fresh TSB media, and viable counts were determined for all cultures at this time (time 0).…”

Synthesis of Some New Azole Derivatives as Antibacterial Agents

“…Phenylthiazoles were originally identified as a thiazole core with a guanidine head and an alkyl chain tail (Elsebaei, Mohammad et al 2018, Hosny, Abutaleb et al 2020 have undergone extensive research and optimization to improve their effectiveness and metabolic profile. While they showed anti-biofilm activity, the poor permeability of the early phenylthiazoles likely contributed to their narrow spectrum (Eid, Elsebaei et al 2017, Helal, Sayed et al 2019, Mancy, Abutaleb et al 2019, Elsebaie, El-Din et al 2022, Sayed, Abutaleb et al 2023. Consequently, changes to the tail led to the third generation, which showed intracellular effectiveness but required further optimization of the metabolic profile(El-Din, , Omara, Hagras et al 2023, Shahin, Mohamed et al 2023, Elbakry, Harras et al 2024).…”