Exploring the styrene metabolism by aerobic bacterial isolates for the effective management of leachates in an aqueous system

Styrene is a nonpolar organic compound used in very high volume for the industrial scale production of commercially important polymers such as polystyrene resins as well as copolymers like acrylonitrile butadiene styrene, latex, and rubber. These resins are widely used in the manufacturing of various products including single‐use plastics such as disposable cups and containers, protective packaging, heat insulation, and so forth. The large‐scale utilization leads to the over‐accumulation of styrene waste in the environment causing deleterious health risks including cancer, neurological impairment, dysbiosis of central nervous system, and respiratory problems. To eliminate the accumulating waste. Microbial enzyme‐based system represents the most environmental friendly and sustainable approach for elimination of styrene waste. However, comprehensive understanding of the enzyme–substrate interaction and associated pathways would be crucial for developing large‐scale disposal systems. This study aims to understand the molecular interaction between the protein‐ligand complexes of the styrene catabolic reactions by bacterial enzymes of sty operon. Molecular docking analysis for catalytic enzymes namely, styrene monooxygenase (SMO), styrene oxide isomerase (SOI), and phenylacetaldehyde dehydrogenase (PAD) of the bacterial sty operon was carried out with their individual substrates, that is, styrene, styrene oxide, and phenylacetic acid, respectively. The binding energy, amino acids forming binding cavity, and binding interactions between the protein‐ligand binding sites were calculated for each case. The obtained binding energies showed a stable association of these complexes indicating the future scope of their utilization for large‐scale bioremediation of styrene, and its commercially used polymers and copolymers.

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Understanding the in silico aspects of bacterial catabolic cascade for styrene degradation

Bhanot

Pali

Panwar

2022

Proteins

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Identification of Volatile Markers in Sweat for COVID‐19 Screening by Gas Chromatography‐Mass Spectrometry

Chuachaina,

Thaveesangsakulthai,

Sinsukudomchai

et al. 2024

ChemistrySelect

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Due to an outbreak of coronavirus spreading in recent years, there is an urgent need for effective, rapid, and non‐invasive diagnostics to detect and differentiate among patients who are infected and uninfected with SARS‐CoV‐2 for controlling the virus propagation. This study developed an alternative method for COVID‐19 screening from volatile analysis of metabolites mainly studied in sweat samples obtained from the populations in Bangkok, Thailand, during December 2020 to April 2022. A total of 140 collected samples; 70 positive confirmed COVID‐19 cases and another 70 negatives confirmed COVID‐19 cases were applied to be separated, detected, and identified as volatile organic compounds (VOCs)/odor occurring from SARS‐CoV‐2 infection body by the technique of Headspace solid‐phase microextraction gas chromatography‐mass spectrometry (HS‐SPME‐GC‐MS) together with principle component analysis (PCA), which allowed potential volatile markers of COVID‐19 such as pentadecane, nonanal, styrene, xylene, ethylbenzene, and 2‐ethylhexyl acrylate (up to 94 % accuracy, 93 % sensitivity, 96 % selectivity, and 94 % specificity), respectively, along with limit of detection in a range of 0.26–125 μg. The result was validated by comparison with the RT‐PCR results.

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Characterization of bacterial cellulose produced by Komagataeibacter xylinus strains grown in styrene/glucose mixtures

Esmail,

Torres,

Ortiz-Albo

et al. 2023

Cellulose

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Exploring the styrene metabolism by aerobic bacterial isolates for the effective management of leachates in an aqueous system

Abstract: Profile of the three potential aerobic bacterial isolates responsible for the metabolism of styrene.

Cited by 3 publications

References 47 publications

Understanding the in silico aspects of bacterial catabolic cascade for styrene degradation

Understanding the in silico aspects of bacterial catabolic cascade for styrene degradation

Identification of Volatile Markers in Sweat for COVID‐19 Screening by Gas Chromatography‐Mass Spectrometry

Characterization of bacterial cellulose produced by Komagataeibacter xylinus strains grown in styrene/glucose mixtures

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