High-resolution, field-scale soil organic carbon (SOC) mapping in croplands is crucial for effective and precise agricultural management. Recent developments in unmanned aerial vehicles (UAVs) combined with miniaturized visible-near infrared spectrometers have enabled the rapid and low-cost field-scale SOC mapping. However, a field-specific spectrotransfer model is often needed for such UAV-based hyperspectral measurements, implying local sampling and model development are still required, and this hampers the widespread application of UAV-based methods. In this study, we aim to test to what extent SOC prediction models derived from an existing regional soil spectral library (SSL) can be applied to UAV-based hyperspectral data, without the need for additional field sampling. To this end, an UAV survey was conducted over a bare cropland within the Belgian Loam Belt for field-scale SOC mapping. We evaluated two calibration approaches, one based on local sampling and model development, and one where we capitalized on an existing (laboratory-based) regional SSL. For the local calibration approach, we obtained a good prediction performance with RMSE of 0.57 g kg À1 and RPIQ of 2.35. For the regional model, a spectral alignment procedure was needed to resolve the discrepancy between UAVand laboratory-based measurements. This resulted in a fair SOC prediction accuracy with RMSE of 0.93 g kg À1 and RPIQ of 1.45. The comparison of SOC maps derived from the two approaches, along with an external validation showed a high consistency, indicating that UAV-based spectral measurements, in combination with SSLs have the potential to improve the efficiency of high-resolution SOC mapping.