2024
DOI: 10.3390/jcm13041153
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Exploring the Therapeutic Potential of Ganoderma lucidum in Cancer

Gabriella Cancemi,
Santino Caserta,
Sebastiano Gangemi
et al.

Abstract: Triterpenoids, such as ganoderic acid, and polysaccharides, including β-D-glucans, α-D-glucans, and α-D-mannans, are the main secondary metabolites of the medicinal fungus Ganoderma lucidum. There is evidence of the effects of ganoderic acid in hematological malignancies, whose mechanisms involve the stimulation of immune response, the macrophage-like differentiation, the activation of MAP-K pathway, an IL3-dependent cytotoxic action, the induction of cytoprotective autophagy, and the induction of apoptosis. I… Show more

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Cited by 3 publications
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“…They found significant improvements in the inflamed gut barrier, evidenced by reduced polyps, a shift from M1 to M2 macrophages in the colon, a favorable adjustment in the E-cadherin/N-cadherin ratio, and a decrease in oncogenic signaling molecules. Additionally, the treatments notably increased the presence of SCFA-producing bacteria and reduced sulfate-reducing bacteria in a time-dependent manner [ 157 ].…”
Section: Fungal Fiber Polysaccharides and Cancer Treatmentmentioning
confidence: 99%
“…They found significant improvements in the inflamed gut barrier, evidenced by reduced polyps, a shift from M1 to M2 macrophages in the colon, a favorable adjustment in the E-cadherin/N-cadherin ratio, and a decrease in oncogenic signaling molecules. Additionally, the treatments notably increased the presence of SCFA-producing bacteria and reduced sulfate-reducing bacteria in a time-dependent manner [ 157 ].…”
Section: Fungal Fiber Polysaccharides and Cancer Treatmentmentioning
confidence: 99%