Exploring the use of nanocarrier systems to deliver the magical molecule; Curcumin and its derivatives

Mehanny, Mina; Hathout, Rania M.; Geneidi, Ahmed S.; Mansour, Samar

doi:10.1016/j.jconrel.2016.01.018

Cited by 158 publications

(106 citation statements)

References 293 publications

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“…[14][15][16] Recently, scientists have shown interest in amphiphilic polymer micelles owing to their core-shell geometry 17,18 and excellent characteristics, such as low toxicity, good biocompatibility and high biodegradability. 19 As a perfect example, methoxy polyethylene glycol-polylactide (mPEG-PLA) polymeric micelles are composed of hydrophilic mPEG and hydrophobic PLA. On one hand, mPEG can act as a hydrophilic shell to reduce the nonspecific uptake by the reticuloendothelial system (RES), thus prolonging the circulation time in blood.…”

mentioning

confidence: 99%

Delivery of curcumin by directed self-assembled micelles enhances therapeutic treatment of non-small-cell lung cancer

Zhu¹,

Liu²,

Wu³

et al. 2017

IJN

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Background It has been widely reported that curcumin (CUR) exhibits anticancer activity and triggers the apoptosis of human A549 non-small-cell lung cancer (NSCLC) cells. However, its application is limited owing to its poor solubility and bioavailability. Therefore, there is an urgent need to develop a new CUR formulation with higher water solubility and better biocompatibility for clinical application in the future. Materials and methods In this study, CUR-loaded methoxy polyethylene glycol–polylactide (CUR/mPEG–PLA) polymeric micelles were prepared by a thin-film hydration method. Their characteristics and antitumor effects were evaluated subsequently. Results The average size of CUR/mPEG–PLA micelles was 34.9±2.1 nm with its polydispersity index (PDI) in the range of 0.067–0.168. The encapsulation efficiency and drug loading were 90.2%±0.78% and 9.1%±0.07%, respectively. CUR was constantly released from the CUR/mPEG–PLA micelles, and its cellular uptake in A549 cells was significantly increased. It was also found that CUR/mPEG–PLA micelles inhibited A549 cell proliferation, increased the cell cytotoxicity, induced G2/M stage arrest and promoted cell apoptosis. Moreover, the CUR/mPEG–PLA micelles suppressed the migration and invasion of A549 cells more obviously than free CUR. Additionally, CUR/mPEG–PLA micelles inhibited human umbilical vein endothelial cells migration, invasion and corresponding tube formation, implying the antiangiogenesis ability. Its enhanced antitumor mechanism may be related to the reduced expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, MMP-9 and Bcl-2 as well as the increased expression of Bax. Conclusion The mPEG–PLA copolymer micelles can serve as an efficient carrier for CUR. The CUR/mPEG–PLA micelles have promising clinical potential in treating NSCLC.

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confidence: 99%

Delivery of curcumin by directed self-assembled micelles enhances therapeutic treatment of non-small-cell lung cancer

Zhu¹,

Liu²,

Wu³

et al. 2017

IJN

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“…It is well known that curcumin is a lipophilic molecule and has been extensively used in food, medicines, and cosmetics due to its various bioactivities [17][18][19][20][21]. However, its delivery is highly limited by its insolubility and instability in biological fluids [22][23][24][25]. So far, it is yet to fulfill its clinical promise in part due to pH-mediated instability [26].…”

Section: Introductionmentioning

confidence: 99%

Effects of Micro-environmental pH of Liposome on Chemical Stability of Loaded Drug

et al. 2017

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Liposome is a promising carrier system for delivering bioactive molecules. However, the successful delivery of pH-sensitive molecules is still limited by the intrinsic instability of payloads in physiological environment. Herein, we developed a special liposome system that possesses an acidic micro-environment in the internal aqueous chamber to improve the chemical stability of pH-sensitive payloads. Curcumin-loaded liposomes (Cur-LPs) with varied internal pH values (pH 2.5, 5.0, or 7.4) were prepared. These Cur-LPs have similar particle size of 300 nm, comparable physical stabilities and analogous in vitro release profiles. Interestingly, the chemical stability of liposomal curcumin in 50% fetal bovine serum and its anticancer efficacy in vitro are both micro-environmental pH-dependent (Cur-LP-2.5 > Cur-LP-5.0 > Cur-LP-7.4). This serum stability still has space to be further enhanced to improve the applicability of Cur-LP. In conclusion, creating an acidic micro-environment in the internal chamber of liposome is feasible and efficient to improve the chemical stability of pH-sensitive payloads.

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“…In recent years, many efforts have been made to increase the potential of curcumin for health promotion and disease prevention, by improving its bioavailability. A large number of research works have focused on innovative formulations intended for oral, pulmonary and topical delivery of curcumin, using innovative ingredients or carrier systems specific for the selected target [8][9][10]. The oral administration of curcumin in innovative carriers represents the most attractive strategy, because it can ensure local delivery and accumulation in the intestines, and improve the systemic biovailability at the same time [11,12].…”

Section: Introductionmentioning

confidence: 99%

Freeze-dried eudragit-hyaluronan multicompartment liposomes to improve the intestinal bioavailability of curcumin

Catalán-Latorre

Ravaghi

Manca

et al. 2016

European Journal of Pharmaceutics and Biopharmaceutics

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Exploring the use of nanocarrier systems to deliver the magical molecule; Curcumin and its derivatives

Cited by 158 publications

References 293 publications

Delivery of curcumin by directed self-assembled micelles enhances therapeutic treatment of non-small-cell lung cancer

Delivery of curcumin by directed self-assembled micelles enhances therapeutic treatment of non-small-cell lung cancer

Effects of Micro-environmental pH of Liposome on Chemical Stability of Loaded Drug

Freeze-dried eudragit-hyaluronan multicompartment liposomes to improve the intestinal bioavailability of curcumin

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