Exploring the Vaginal Microbiome and Intravaginal Practices in Postmenopausal Women

Daniel, Gaea; Hu, Yingtian; Tsementzi, Despina; Jhaney, Camber Ileen; Hu, Yi‐Juan; Yeager, Katherine A.; Bai, Jinbing; Dolan, M. Eileen; Bruner, Deborah Watkins

doi:10.1097/nnr.0000000000000538

Cited by 2 publications

(1 citation statement)

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“…The resultant environment is essential for preventing a number of anaerobic and microaerophilic pathogens from colonizing the vagina, which can lead to lactobacilli depletion and dysbiosis [an imbalance of the vaginal population], also known as bacterial vaginosis [BV] [4] . BV has been connected to a number of adverse obstetric and gynecologic health outcomes in both pre-and postmenopausal women [5] . Sexually transmitted diseases and gynecologic infections are more likely to affect postmenopausal women when the vaginal microbiome is disrupted.…”

Section: Introductionmentioning

confidence: 99%

Comparison of The Vaginal Microflora in Relation to The Menopausal Status

Atallah,

Moustafa,

Eltabakh

2023

International Journal of Medical Arts

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Article informationBackground: Numerous bacteria live in the human vagina;because of this, it has been discovered that the vaginal microbiome is directly related to both vaginal and overall health. Aim of the work:In this study, we sought to evaluate the vaginal microbiomes of premenopausal and postmenopausal women. Patients and Methods:This was a comparative cross section study, was carried out on 120 patients who divided in to two groups as regard menopausal state in to Group A: 60 women in Premenopausal group and Group B: 60 women in Post-Menopausal group, vaginal samples were obtained from all studied women.Results: As regard bacterial distribution according to Phylum; there was a significant difference between two groups regarding Firmicutes and Proteobacteria which were higher among premenopausal women. Conclusion:Women in each study group had different vaginal ecosystems in terms of the relative quantity and composition of the dominating bacterial species. While species diversity greatly increased in postmenopausal women, species richness significantly declined. After menopause, the most significant difference between the two groups was caused by a decline in Lactobacillus taxa, which are represented by all taxon ranks of the vaginal microbiome.

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Section: Introductionmentioning

confidence: 99%

Comparison of The Vaginal Microflora in Relation to The Menopausal Status

Atallah,

Moustafa,

Eltabakh

2023

International Journal of Medical Arts

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Vaginal microbiome community state types and high-risk human papillomaviruses in cervical precancer and cancer in North-central Nigeria

et al. 2023

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Background High risk human papillomaviruses (HR-HPV) have a causal role in cervical oncogenesis, and HIV-mediated immune suppression allows HR-HPV to persist. We studied whether vaginal microbiome community state types (CSTs) are associated with high-grade precancer and/or invasive cervical cancer (HSIL/ICC). Methods This was a cross-sectional study of adult women with cervical cancer screening (CCS) at the Jos University Teaching Hospital (JUTH) in Jos, Nigeria, between January 2020 and February 2022. Cervical swabs underwent HPV genotyping (Anyplex™ II HPV28). Cervico-vaginal lavage (CVL) sample was collected for 16 S rRNA gene amplicon sequencing. We used multivariable logistic regression modelling to assess associations between CSTs and other factors associated with HSIL/ICC. Results We enrolled 155 eligible participants, 151 with microbiome data for this analysis. Women were median age 52 (IQR:43–58), 47.7% HIV positive, and 58.1% with HSIL/ICC. Of the 138 with HPV data, 40.6% were negative for HPV, 10.1% had low-risk HPV, 26.8% had single HR-HPV, and 22.5% had multiple HR-HPV types. The overall prevalence of any HR-HPV type (single and multiple) was 49.3%, with a higher proportion in women with HSIL/ICC (NILM 31.6%, LSIL 46.5%, HSIL 40.8%, and 81.5% ICC; p = 0.007). Women with HIV were more likely to have HSIL/ICC (70.3% vs. 29.7% among women without HIV). In crude and multivariable analysis CST was not associated with cervical pathology (CST-III aOR = 1.13, CST-IV aOR = 1.31). However, in the presence of HR-HPV CST-III (aOR = 6.7) and CST-IV (aOR = 3.6) showed positive association with HSIL/ICC. Conclusion Vaginal microbiome CSTs were not significantly associated with HSIL/ICC. Our findings suggest however, that CST could be helpful in identifying women with HSIL/ICC and particularly those with HR-HPV. Characterization of CSTs using point-of-care molecular testing in women with HR-HPV should be studied as an approach to improve early detection and cervical cancer prevention. Future longitudinal research will improve our understanding of the temporal effect of non-optimal CST, HR-HPV, and other factors in cervical cancer development, prevention, and control.

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Exploring the Vaginal Microbiome and Intravaginal Practices in Postmenopausal Women

Cited by 2 publications

References 39 publications

Comparison of The Vaginal Microflora in Relation to The Menopausal Status

Comparison of The Vaginal Microflora in Relation to The Menopausal Status

Vaginal microbiome community state types and high-risk human papillomaviruses in cervical precancer and cancer in North-central Nigeria

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