Exploring therapeutic mechanisms of San-Huang-Tang in nonalcoholic fatty liver disease through network pharmacology and experimental validation

Shi, Huilian; Qiao, Fei; Kaiyue, Huang; Lu, Wei-Ting; Zhang, Xinzhuang; Ke, Zhipeng; Wu, Yanchi; Cao, Liang; Chen, Yuanyuan

doi:10.1016/j.jep.2022.115477

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…Tianhuang Formula increases the abundance of Lactobacillus and the content of 5-MIAA in the intestinal contents and liver to reduce the expression of Nrf2 and oxidative stress, thereby improving NAFLD [ 159 ]. Sanhuang Tang alleviates insulin resistance by activating the INSR/IRS1/AKT/FoxO1 pathway, which contributes to NAFLD treatment [ 160 ].…”

Section: Non-pharmacological Treatment Of Nafld In Western Medicinementioning

confidence: 99%

Integrated traditional Chinese and Western medicine in the prevention and treatment of non-alcoholic fatty liver disease: future directions and strategies

Ding,

He,

Tang

et al. 2024

Chin Med

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Traditional Chinese medicine (TCM) has been widely used for several centuries for metabolic diseases, including non-alcoholic fatty liver disease (NAFLD). At present, NAFLD has become the most prevalent form of chronic liver disease worldwide and can progress to non-alcoholic steatohepatitis (NASH), cirrhosis, and even hepatocellular carcinoma. However, there is still a lack of effective treatment strategies in Western medicine. The development of NAFLD is driven by multiple mechanisms, including genetic factors, insulin resistance, lipotoxicity, mitochondrial dysfunction, endoplasmic reticulum stress, inflammation, gut microbiota dysbiosis, and adipose tissue dysfunction. Currently, certain drugs, including insulin sensitizers, statins, vitamin E, ursodeoxycholic acid and betaine, are proven to be beneficial for the clinical treatment of NAFLD. Due to its complex pathogenesis, personalized medicine that integrates various mechanisms may provide better benefits to patients with NAFLD. The holistic view and syndrome differentiation of TCM have advantages in treating NAFLD, which are similar to the principles of personalized medicine. In TCM, NAFLD is primarily classified into five types based on clinical experience. It is located in the liver and is closely related to spleen and kidney functions. However, due to the multi-component characteristics of traditional Chinese medicine, its application in the treatment of NAFLD has been considerably limited. In this review, we summarize the advances in the pathogenesis and treatment of NAFLD, drawn from both the Western medicine and TCM perspectives. We highlight that Chinese and Western medicine have complementary advantages and should receive increased attention in the prevention and treatment of NAFLD.

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Section: Non-pharmacological Treatment Of Nafld In Western Medicinementioning

confidence: 99%

Integrated traditional Chinese and Western medicine in the prevention and treatment of non-alcoholic fatty liver disease: future directions and strategies

Ding,

He,

Tang

et al. 2024

Chin Med

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show abstract

“…The classic prescription San-Huang Tang (SHT) has been clinically used in the treatment of diseases such as type 2 diabetes and obesity, and SHT has recently been proven to have a good therapeutic effect on NAFLD. Shi, et al (2022) found through bioinformatic screening and in vivo and in vitro experimental verification that SHT further affects insulin resistance by activating INSR/IRS1/AKT/FoxO1 pathway, and finally exerts the therapeutic effect of NAFLD. This study not only provides a solid experimental basis for the therapeutic effect of SHT but also provides a solid experimental basis for the therapeutic effect of SHT.…”

Section: Network Pharmacological Study On Non-alcoholic Fatty Liver D...mentioning

confidence: 99%

Chinese medicine in the treatment of non-alcoholic fatty liver disease based on network pharmacology: a review

Zheng,

Xue,

et al. 2024

Front. Pharmacol.

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Non-alcoholic fatty liver disease (NAFLD) is a clinicopathological syndrome characterized by abnormalities in hepatic fat deposition, the incidence of which has been increasing year by year in recent years. It has become the largest chronic liver disease globally and one of the important causes of cirrhosis and even primary liver cancer formation. The pathogenesis of NAFLD has not yet been fully clarified. Modern medicine lacks targeted clinical treatment protocols for NAFLD, and most drugs lack efficacy and have high side effects. In contrast, Traditional Chinese Medicine (TCM) has significant advantages in the treatment and prevention of NAFLD, which have been widely recognized by scholars around the world. In recent years, through the establishment of a “medicine-disease-target-pathway” network relationship, network pharmacology can explore the molecular basis of the role of medicines in disease prevention and treatment from various perspectives, predicting the pharmacological mechanism of the corresponding medicines. This approach is compatible with the holistic view and treatment based on pattern differentiation of TCM and has been widely used in TCM research. In this paper, by searching relevant databases such as PubMed, Web of Science, and Embase, we reviewed and analyzed the relevant signaling pathways and specific mechanisms of action of single Chinese medicine, Chinese medicine combinations, and Chinese patent medicine for the treatment of NAFLD in recent years. These related studies fully demonstrated the therapeutic characteristics of TCM with multi-components, multi-targets, and multi-pathways, which provided strong support for the exact efficacy of TCM exerted in the clinic. In conclusion, we believe that network pharmacology is more in line with the TCM mindset of treating diseases, but with some limitations. In the future, we should eliminate the potential risks of false positives and false negatives, clarify the interconnectivity between components, targets, and diseases, and conduct deeper clinical or experimental studies.

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Analysis of network pharmacology and experimental verification to explore the mechanism of Modified Guilu Erxian Glue in the treatment of low immune function

Wang

Gao

et al. 2023

Pharmacological Research - Modern Chinese Medicine

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Exploring therapeutic mechanisms of San-Huang-Tang in nonalcoholic fatty liver disease through network pharmacology and experimental validation

Cited by 4 publications

References 35 publications

Integrated traditional Chinese and Western medicine in the prevention and treatment of non-alcoholic fatty liver disease: future directions and strategies

Integrated traditional Chinese and Western medicine in the prevention and treatment of non-alcoholic fatty liver disease: future directions and strategies

Chinese medicine in the treatment of non-alcoholic fatty liver disease based on network pharmacology: a review

Analysis of network pharmacology and experimental verification to explore the mechanism of Modified Guilu Erxian Glue in the treatment of low immune function

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