Religion is an important factor of life satisfaction for adolescents. This relationship is complex and depends on religiousness indicators used, religious affiliation, sex, age, and some cultural aspects. The aim of the study was to examine whether positive religious coping moderates the relationships between religious practices, as well as God’s support and life satisfaction. Additionally, the mediating role of religious commitment between faith and life satisfaction was tested. Methods: The sample in this study consisted of 315 Polish Roman Catholic female students. The following tools were used: the Satisfaction with Life Scale (SWLS), the Santa Clara Strength of Religious Faith Questionnaire (SCSORFQ), the Brief Religious Coping Scale (Brief RCOPE), the Religious Support Scale (RSS), and two one-item measures regarding frequency of prayer and Mass attendance. Results: The moderating role of positive religious coping between prayer, as well as God’s support and life satisfaction, was confirmed. Additionally, positive religious coping, God’s support, prayer, and Mass attendance mediated between faith and life satisfaction. Conclusion: The research has proven that faith negatively influenced adolescents’ life satisfaction both directly and directly through positive religious coping and Mass attendance. A beneficial indirect effect of faith on life satisfaction through God’s support and prayer was confirmed. It was also found that using positive religious coping with an above-average frequency of religious practices improved the life satisfaction among female students.