2011
DOI: 10.1038/cmi.2010.70
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Explosion of autoimmune diseases and the mosaic of old and novel factors

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Cited by 42 publications
(16 citation statements)
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“…The net increased incidences/prevalences of ADs in the Northern and Western countries, compared to the Southern and Eastern ones follows the global geoepidemiological trends of autoimmune diseases [9,10]. By reviewing available literature, it can be deduced that frequency of ADs have increased significantly over the last 30 years.…”
Section: Discussionmentioning
confidence: 99%
“…The net increased incidences/prevalences of ADs in the Northern and Western countries, compared to the Southern and Eastern ones follows the global geoepidemiological trends of autoimmune diseases [9,10]. By reviewing available literature, it can be deduced that frequency of ADs have increased significantly over the last 30 years.…”
Section: Discussionmentioning
confidence: 99%
“…Over the course of the last decades, the frequency of autoimmune diseases has been increasing significantly [373]. 5-10% of people worldwide suffer from autoimmune diseases although some studies estimate the numbers to be as high as 20% [374]. The current treatment strategies for this disease group largely rely on immunosuppressive drugs that nonspecifically target certain parts of the adaptive immune system to control its aberrant immune responses.…”
Section: Concluding Remarks and Perspectivesmentioning
confidence: 99%
“…Autoimmune diseases affect 5–10% of the population worldwide [ 27 ], translating to hundreds of millions of lives impacted. Autoimmune diseases are burgeoning globally [ 28 ], and as a group are equivalent in prevalence to heart disease, and twice that of cancer [ 29 , 30 ]. Immune-modifying therapies used to treat autoimmune diseases have significant risks for life-threatening infection, including those caused by opportunistic and pathogenic fungi [ 31 , 32 ].…”
Section: Significance Of Fungal Infectionsmentioning
confidence: 99%