An essential concept in decision-making is the correlation coefficient. Because decision-making is so complex, fuzzy logic is used to make decisions that can be trusted. The concept of a q-rung orthopair fuzzy logic is the way to go in order to achieve a trustworthy decision-making, particularly when based on the q-rung orthopair fuzzy correlation coefficient. This work introduces and discusses two new methods for estimating correlation coefficient under q-ROFSs (CCq-ROFs). To support the alignment of the CCq-ROFs techniques with the traditional correlation coefficient, we present some of their attributes. Furthermore, we utilize simulated q-rung orthopair fuzzy data based on recognition principle and multiple criteria decision-making (MCDM) approach to apply the new CCq-ROFs techniques in disease diagnosis and employment process. In order to determine the advantages of the new CCq-ROFs techniques over the existing techniques in terms of reliability and performance rating, a brief comparison of the two sets of techniques is presented at the end.