Differential equations are commonly used to model several engineering, science, and biological applications. Unfortunately, finding analytical solutions for solving higher-order Ordinary Differential Equations (ODEs) is a challenge. Numerical methods represent a leading candidate for solving such ODEs. This work presents an innovated adaptive technique that uses polynomials to solve linear or nonlinear third-order ODEs. The proposed technique adapts the coefficients of the polynomial to obtain an explicit analytical solution. A signed least mean square algorithm is exploited to enhance the adaptation process and to decrease both computational requirements and time. The efficiency of the proposed Adaptive Polynomial Method (APM) is illustrated through six well-known examples. The proposed technique is compared with recent analytical and numerical methods to validate its effectiveness in terms of Mean Square Error (MSE) and computation time. An application in a thin film flow system is modeled to a third-order ODE. The proposed technique is compared with recent numerical and analytical methods in solving the thin film flow equation, and the proposed technique has achieved better results. Furthermore, the proposed technique provides an analytical solution with an increased dynamic range and much lower computational time than those of the conventional numerical methods.