Export competitiveness is important in globalizing world. High technology exporter countries can increase their export volume and value more easily than the countries exporting primary goods because of high income elasticity in hightechnology products.In this context this study investigates the main determinants of high-technology exports by using a wide panel data set and a wide range of economic, political and institutional variables for 48 countries which cover %90 percent of total hightechnology/total manufactured export ratio. To this aim, panel ARDL methodology have been employed to examine the long run effect of indicators such as, schooling, per capita income, trade openness, foreign direct investments, domestic saving, political stability, reel effective exchange rate and patent applications for the period from 1980 to 2017. Estimation results show that trade openness, FDI inflows, per capita income and schooling are the important factors that affect hightechnology export performance of sample countries.