Exposed-core microstructured optical fibers for real-time fluorescence sensing

Warren‐Smith, Stephen C.; Ebendorff-Heidepriem, Heike; Foo, Tze Cheung; Moore, R. C.; Davis, Claire; Monro, Tanya M.

doi:10.1364/oe.17.018533

Cited by 90 publications

(82 citation statements)

References 23 publications

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“…ECF is a special type of microstructured optical fiber whose suspended core is exposed to the surrounding medium thanks to an open side of the ECF cladding [18]. It is typically fabricated by drilling holes along a silica rod [19] to form a suspended core fiber preform.…”

Section: Multimode Interference In Exposed Core Microstructured Opticmentioning

confidence: 99%

“…To solve this issue we have developed a special type of optical fiber called exposed-core microstructured optical fiber (ECF) [17][18][19]. Of its many advantageous characteristics compared with conventional microstructured optical fibers, the most distinctive one is that ECF can be spliced with standard SMFs to form all-fiber configuration [20], while the light propagating in the core still has direct contact with analyte suspended in the surrounding medium thanks to the exposed core.…”

Section: Introductionmentioning

confidence: 99%

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Interferometric-type optical biosensor based on exposed core microstructured optical fiber

Nguyen

Hill

Warren‐Smith

et al. 2015

Sensors and Actuators B: Chemical

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In all cases accepted manuscripts should:  link to the formal publication via its DOI  bear a CC-BY-NC-ND license -this is easy to do, click here to find out how  if aggregated with other manuscripts, for example in a repository or other site, be shared in alignment with our hosting policy  not be added to or enhanced in any way to appear more like, or to substitute for, the published journal article Abstract: This work presents a novel biosensor using the multimode interference effect in an exposed core microstructured optical fiber (ECF). In this work biotin molecules are immobilized onto the ECF core surface to serve as the capturing probe for streptavidin, the target molecules.Since each distinct guided mode in the ECF interacts with the surrounding medium differently, the interference between any two specific modes will experience a fringe shift (or phase change) upon a change in the refractive index (RI) of the surrounding medium, or a localized RI change on the surface of the ECF core as a result of a biological binding event. In our experiment, the interferometric sensing platform was realized by splicing a section of ECF with lead-in and leadout single mode fibers (SMFs). An interference pattern is obtained in the transmission spectrum as the result of multiple excited modes (excited and re-collected at the lead-in and lead-out splicing points) propagating in the ECF with different propagation constants. The interference pattern is non-uniform, indicating that there are more than two modes involved. Fast Fourier transform (FFT) is used to separate individual interference patterns that contribute to this complex spectrum and monitor their phase changes upon RI variation of the surrounding medium. In this way multiple RI sensitivities can be realized because each spatial frequency possesses a distinct sensitivity with respect to the surrounding RI. The operation of this device was validated by measuring the phase changes that occur when the sensing platform was subjected to solutions of different RIs or functionalized with different molecules. A biosensor was demonstrated based on this novel platform using biotin as the capturing probe to detect streptavidin with low non-specific adsorption. The proposed platform is reliable, cost-effective, and offers a potential label-free biosensing alternative to the widely used surface plasmon resonance (SPR) technique.

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Section: Multimode Interference In Exposed Core Microstructured Opticmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interferometric-type optical biosensor based on exposed core microstructured optical fiber

Nguyen

Hill

Warren‐Smith

et al. 2015

Sensors and Actuators B: Chemical

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“…The WW preform was then drawn to a cane (~1 mm diameter), using a fibre drawing tower, then inserted into an extruded F2 soft glass wedged jacket (sleeve). The cane-in-jacket preform was then drawn to fibre with an outer diameter of ~160 µm diameter (top-right of Figure 7) where the ~3 µm effective diameter core, in the exposed region highlighted by the green box, is suspended by three thin struts [26]. An enlarged view of the exposed core structured region of the fibre is shown in the bottom-right view of Figure 7.…”

Section: Microstructured Optical Fibres (Mofs)mentioning

confidence: 99%

“…An enlarged view of the exposed core structured region of the fibre is shown in the bottom-right view of Figure 7. (Left) Schematic diagram of F2 soft glass exposed-core fibre fabrication process, with scanning electron microscope images of (top-right) the resulting exposed-core fibre with a outside diameter of ~160 µm; with an enlargement of the area highlighted by the green box (bottom-right) showing the core, hole and strut structured region, where the core has an effective diameter of ~3.0 µm [26].…”

Section: Microstructured Optical Fibres (Mofs)mentioning

confidence: 99%

“…The fabrication of a microstructured fibre with the core exposed along the whole length provides near-instantaneous measurements of fluorescence intensity while additionally allowing the opportunity for spatial measurements along the length of the fibre through temporal detection methods such as OTDR [26]. High purity fused silica Suprasil F300HQ was chosen because of its low hydroxide (OH) content and availability with tight geometric tolerances [32].…”

Section: Silica Exposed-core Fibresmentioning

confidence: 99%

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Optical Fibres for Distributed Corrosion Sensing - Architecture and Characterisation

Kostecki

Ebendorff-Heidepriem

Warren‐Smith

et al. 2013

KEM

Self Cite

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This paper summarises recent work conducted on the development of exposed core microstructured optical fibres for distributed corrosion sensing. Most recently, exposed-core fibres have been fabricated in silica glass, which is known to be reliable under a range of processing and service environments. We characterise the stability of these new silica fibres when exposed to some typical sensing and storage environments. We show the background loss to be the best achieved to date for exposed-core fibres, while the transmission properties are up to ~2 orders of magnitude better than for the previously reported exposed-core fibres produced in soft glass. This provides a more robust fibre platform for corrosion sensing conditions and opens up new opportunities for distributed optical fibre sensors requiring long-term application in harsh environments.

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Evolutive Optical Fibers Combining Oxide and Chalcogenide Glasses with Submicronic Polymer Structures

Strutynski

Deroh

Evrard

et al. 2022

Advanced Photonics Research

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Multimaterial optical fibers combining tellurite with chalcogenide glasses and featuring thin polymer structures are fabricated via the thermal drawing process. It is demonstrated that micrometric polyethersulfone films can be embedded within larger elongated tellurite/chalcogenide glass architectures. Taking advantage of the strong chemical reactivity contrasts which exist in the considered fiber geometries, a quasi‐exposed‐core waveguide is obtained by selective etching of the glass cladding. The potential of the postprocessed fiber structure is then assessed through evanescent‐wave probing of liquids and numerical investigations are carried out to establish the device performances as function of selected optogeometric parameters. Those results open the way for the development of evolutive photonic objects benefiting from postdrawing processing of multimaterial fibers.

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Exposed-core microstructured optical fibers for real-time fluorescence sensing

Cited by 90 publications

References 23 publications

Interferometric-type optical biosensor based on exposed core microstructured optical fiber

Interferometric-type optical biosensor based on exposed core microstructured optical fiber

Optical Fibres for Distributed Corrosion Sensing - Architecture and Characterisation

Evolutive Optical Fibers Combining Oxide and Chalcogenide Glasses with Submicronic Polymer Structures

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