Exposed: The Many and Varied Roles of Phospholipase C γ SH2 Domains

Driscoll, Paul C.

doi:10.1016/j.jmb.2015.06.002

Cited by 3 publications

(1 citation statement)

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“…There are two isoforms of PLCγ, PLCγ1 and PLCγ2. PLCγ1 is ubiquitously expressed, and operates downstream of tyrosine kinase growth factor receptors such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), PDGF and EGF, whereas PLCγ2 is primarily expressed in hematopoietic cell lineages, often functioning downstream of immune cell receptors (Figure 1 and [113,114]). PLCγ subtypes are primarily activated by receptor tyrosine kinases (RTKs).…”

Section: Plcγ 12mentioning

confidence: 99%

Phospholipase C

Bill

Vines

2019

Advances in Experimental Medicine and Biology

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Phospholipase C (PLC) family members constitute a family of diverse enzymes. Thirteen different family members have been cloned. These family members have unique structures that mediate various functions. Although PLC family members all appear to signal through the bi-products of cleaving phospholipids, it is clear that each family member, and at times each isoform, contributes to unique cellular functions. This chapter provides a review of the current literature on PLC. In addition, references have been provided for more in-depth information regarding areas that are not discussed including tyrosine kinase activation of PLC. Understanding the roles of the individual PLC enzymes, and their distinct cellular functions, will lead to a better understanding of the physiological roles of these enzymes in the development of diseases and the maintenance of homeostasis.

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Section: Plcγ 12mentioning

confidence: 99%