This chapter reviews the toxicology of some of the most commonly encountered chemicals in environmental and occupational settings. Although these chemicals are often generated by industrial processes such as combustion, several are generated by natural processes including endogenous production within the body. These substances are basic to the biological process and therefore life itself. Nonetheless, excessive exposures can be life‐threatening and must be controlled. This chapter is modeled after the excellent, previous chapter in this series written by Michael J. Lipsett, Dennis J. Shusterman, and Rodney R. Beard.