Exposure assessment of epidermal growth factor to various tissues in mice after intravenous and subcutaneous administration

Abstract

Based on Cmax and AUC data, the systemic exposure achieved by subcutaneous injections was comparable with that achieved by intravenous injections.

Epidermal growth factor treatment of female mice that express APOE4 at an age of advanced pathology mitigates behavioral and cerebrovascular dysfunction

“…After i.v. and s.c. injections, EGF is cleared rapidly from the plasma in wild-type rodents (low levels 2 h after treatment) [70]. It is important to evaluate whether the pharmacokinetics of EGF are similar in wild-type mice and E4FAD mice during treatment.…”

Preclinical Systemic Pharmacokinetics, Dose Proportionality, and Central Nervous System Distribution of the ATM Inhibitor WSD0628, a Novel Radiosensitizer for the Treatment of Brain Tumors

“…Dose proportionality was assessed for AUC and C max using the power model (Wixley, 1997;Lee et al, 2015). The proportionality between each parameter and dose was determined using Equation ( 3), where parameter is AUC or C max , α is a coefficient and β is the proportionality constant.…”

Epidermal growth factor receptor (EGFR) inhibition by polychlorinated biphenyls contributes to non-alcoholic fatty liver disease (NAFLD).

“…Aroclor exposure diminishes CK2 activity and reduces expression of the a and b subunits but increases the expression of the a' subunit…………………………………………….. 101 28. Aroclor exposure promotes secondary necrosis in TASH………………………………...103 29. EGF rescues hepatic EGFR signaling in PCB-exposed mice and downregulates CAR NAFLD is a spectrum of diseases ranging from simple steatosis (lipid accumulation) which can progress to steatohepatitis (chronic inflammation).…”

“…Recently EGFR has been implicated in adult liver homeostasis (28). While EGFR is highly expressed in the liver and 60% of labeled EGF traffics to the liver little is known about its role in liver function and homeostasis (29). Recently EGFR signaling has been shown to peak in the inactive phase in murine liver suggesting it may be integral for fasting responses in the liver (28) ( Figure 4).…”