Organic solvents are common chemicals used in wood furniture manufacturing to modify the pigments and resins in paint for ease of application on surfaces being prepared for painting. 1,2 The solvents help reduce the viscosity of paints. 2 Many of these solvents are heavily laden with volatile organic compounds (VOC) which have been shown to be a risk factor for various diseases, hence the need for a multi-dimensional approach to limiting exposure, such as setting exposure limits and advocacy for adoption of standard practices such as the use of personal protective equipment. 3,4 Common VOCs that have been identified in the furniture-making industry include acetone, butane-2-one, ethyl, isobutyl and methoxy propyl acetate, 4-methylpentan-2-on, toluene, ethylbenzene, and xylenes. 5 Background. Furniture making industries are small scale businesses that commonly use organic solvents. There has been minimal focus on the health effects of this chemical hazard on the nervous system among furniture makers in Nigeria. Objectives. The present study aimed to assess the association between organic solvents exposure and neurobehavioral status of furniture makers, using electronic technicians as a comparison group. Methods. A comparative cross-sectional study design was employed. A sample size of 108 was calculated for each group. A semi-structured interviewer-administered questionnaire was used to obtain data on the socio-demographic variables and use of personal protective equipment (PPE). A proforma was developed to collect neurobehavioral assessment data. A checklist was used to assess the furniture makers' workshops. Air was sampled from all of the workshops in both the study and comparison groups to determine the concentration of total volatile organic compounds (TVOCs). Results. The use of PPE was poor in both the study and comparison groups, with no significant difference between them (34.4% and 37.7% respectively). Total volatile organic compound and formaldehyde (HCHO) concentrations were significantly higher at the furniture makers' workshops compared with electronic technicians (p<0.001) for both chemicals. The 8-hour time-weighted average of TVOC was also higher in the furniture makers' workshops (4.4±0.6 mg/m 3) compared with the control group (0.3±0.3 mg/m 3). The neurobehavioral symptoms score was significantly higher among the study group relative to the comparison group (p<0.001). There was a significant difference in the outcome of the auditory verbal learning test, total recall (p=0.005), and delayed recall (p=0.003). There was no significant association between solvent exposure index and findings from the simple reaction time test Conclusions. Poor compliance with the use of PPE among furniture makers may increase their exposure to organic solvents. There were more neurobehavioral changes in the furniture makers with a higher exposure index. Measures are needed to educate artisans about workrelated chemical hazards and ensure compliance with basic occupational safety and hygiene standards.