Exposure of few layer graphene to Limnodrilus hoffmeisteri modifies the graphene and changes its bioaccumulation by other organisms

Mao, Liang; Liu, Chuanling; Lü, Kun; Su, Yu; Gu, Cheng; Huang, Qingguo; Petersen, Elijah J.

doi:10.1016/j.carbon.2016.08.037

Cited by 50 publications

(38 citation statements)

References 52 publications

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“…Interestingly, there was an increase in the bioaccumulation factor for earthworms exposed to FLG when the FLG had been wrapped with proteins. 16 One hypothesis for this finding was that the protein coating caused the FLG to interact differently with the microvilli in the gut tract, which would be similar to results observed in this study. Figure 6B shows an image of intestinal epithelial cells (obtained from the S-FLG exposure sample), which were subsequently sectioned for TEM analysis.…”

Section: Resultssupporting

confidence: 80%

Biological Uptake, Distribution, and Depuration of Radio-Labeled Graphene in Adult Zebrafish: Effects of Graphene Size and Natural Organic Matter

Lü¹,

Dong²,

et al. 2017

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The exciting commercial application potential of graphene materials may inevitably lead to their increasing release into the environment where they may pose ecological risks. This study focused on using carbon-14 labeled few-layer graphene (FLG) to determine whether the size of graphene plays a role in its uptake, depuration and biodistribution in adult zebrafish. After 48 h exposure to larger FLG (L-FLG) at 250 μg/L, the amount of graphene in the organism was close to 48 mg/kg fish dry mass, which was more than 170-fold greater than the body burden of those exposed to the same concentration of smaller FLG (S-FLG). The amount of uptake for both L-FLG and S-FLG increased by a factor of 2.5 and 16, respectively, when natural organic matter (NOM) was added in the exposure suspension. While the L-FLG mainly accumulated in the gut of adult zebrafish, the S-FLG was found in both the gut and liver after exposure with or without NOM. Strikingly, the S-FLG was able to pass through the intestinal wall and enter the intestinal epithelial cells and blood. The presence of NOM increased the quantity of S-FLG in these cells. Exposure to L-FLG or S-FLG also had a significantly different impact on the intestinal microbial community structure.

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Section: Resultssupporting

confidence: 80%

Biological Uptake, Distribution, and Depuration of Radio-Labeled Graphene in Adult Zebrafish: Effects of Graphene Size and Natural Organic Matter

Lü¹,

Dong²,

et al. 2017

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“…In addition, similar results have been observed when bioaccumulation studies were conducted in the same or different laboratories using orthogonal techniques (e.g., infrared fluorescence methods and radioactive labeling 52 or the microwave method 70 and radioactive labeling 54, 56 ). Lastly, similar findings have been observed in studies investigating the bioaccumulation of radioactively labeled few layer graphene for several of the same ecological receptors 71, 72 .…”

Section: Discussionsupporting

confidence: 83%

Increasing evidence indicates low bioaccumulation of carbon nanotubes

Bjorkland

Tobias

Petersen

2017

Environ. Sci.: Nano

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As the production of carbon nanotubes (CNTs) expands, so might the potential for release into the environment. The possibility of bioaccumulation and toxicological effects has prompted research on their fate and potential ecological effects. For many organic chemicals, bioaccumulation properties are associated with lipid-water partitioning properties. However, predictions based on phase partitioning provide a poor fit for nanomaterials. In the absence of data on the bioaccumulation and other properties of CNTs, the Office of Pollution Prevention and Toxics (OPPT) within the US Environmental Protection Agency (EPA) subjects new pre-manufacture submissions for all nanomaterials to a higher-level review. We review the literature on CNT bioaccumulation by plants, invertebrates and non-mammalian vertebrates, summarizing 40 studies to improve the assessment of the potential for bioaccumulation. Because the properties and environmental fate of CNTs may be affected by type (single versus multiwall), functionalization, and dosing technique, the bioaccumulation studies were reviewed with respect to these factors. Absorption into tissues and elimination behaviors across species were also investigated. All of the invertebrate and non-mammalian vertebrate studies showed little to no absorption of the material from the gut tract to other tissues. These findings combined with the lack of biomagnification in the CNT trophic transfer studies conducted to date suggest that the overall risk of trophic transfer is low. Based on the available data, in particular the low levels of absorption of CNTs across epithelial surfaces, CNTs generally appear to form a class that should be designated as a low concern for bioaccumulation.

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“…Our previous study demonstrated that daphnids were able to accumulate extraordinarily high AgNP concentrations (up to 22.9 mg/g) in their digestive tract without apparent toxic effects observed [15,21]. Many other studies also have shown that after exposure to nano-TiO 2 , carbon nanotubes, graphene, and fullerenes, the majority of them could be found in the gut of Daphnia [23,[30][31][32]. However, in the present study we emphasized that the most sensitive target of Daphnia exposed to AgNPs should be the nongut tissue.…”

Section: Discussionmentioning

confidence: 94%

Bioaccumulation‐based silver nanoparticle toxicity in Daphnia magna and maternal impacts

Pakrashi

Tan

Wang

2017

Enviro Toxic and Chemistry

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In the present study, we tested whether bioaccumulation in specific tissues of Daphnia magna could explain silver nanoparticle (AgNP) toxicity. Daphnids were exposed to different concentrations of well-suspended AgNPs and AgNO . The accumulations of Ag in the whole body, gut, and nongut tissues, as well as the mortality of daphnids, were recorded over a period of 7 d. Regression analysis showed a higher degree of positive correlation between the concentration of Ag in the nongut tissues than gut tissues and the mortality of daphnids. The results strongly suggested that the toxicity of AgNPs could be better explained in terms of bioaccumulation of AgNPs in the nongut tissues. We further tested the maternal transfer of AgNPs in daphnids into the next generation using radioactive tracers, which were able to detect as low as 1.0 to 3.2% of total accumulated Ag transferred to the neonates. The AgNPs significantly affected the reproduction process during the first 2 broods after exposure, whereas AgNO only had significant effects on the first brood. It is possible that AgNPs have longer adverse effects than AgNO on the reproduction of Daphnia. The present study identified the sensitive site of AgNP toxic action in daphnids and documented the extent of maternal transfer and the significant influence of AgNPs on the reproduction of daphnids. Environ Toxicol Chem 2017;36:3359-3366. © 2017 SETAC.

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Exposure of few layer graphene to Limnodrilus hoffmeisteri modifies the graphene and changes its bioaccumulation by other organisms

Cited by 50 publications

References 52 publications

Biological Uptake, Distribution, and Depuration of Radio-Labeled Graphene in Adult Zebrafish: Effects of Graphene Size and Natural Organic Matter

Biological Uptake, Distribution, and Depuration of Radio-Labeled Graphene in Adult Zebrafish: Effects of Graphene Size and Natural Organic Matter

Increasing evidence indicates low bioaccumulation of carbon nanotubes

Bioaccumulation‐based silver nanoparticle toxicity in Daphnia magna and maternal impacts

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