Exposure of human cartilage tissue to low concentrations of blood for a short period of time leads to prolonged cartilage damage: An in vitro study

Jansen, N.W.; Roosendaal, G.; Bijlsma, J. W. J.; DeGroot, Jeroen; Lafeber, Floris P. J. G.

doi:10.1002/art.22304

Cited by 116 publications

(124 citation statements)

References 37 publications

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“…32 Furthermore, joint bleeding affects the synovial tissue, resulting in synovitis and subsequent articular cartilage damage, mainly caused by the excretion of tissue-destructive mediators, such as enzymes and cytokines. 14,15,[33][34][35] In conclusion, our results suggest that there are clinical differences between HB and HA and that the degree of arthropathy is more severe in HA patients, as supported by the higher number of hemarthrosis and lower levels of OPG both in serum and synovium. Our data suggest that the synovitis may play a crucial role in blood-induced arthropathy provoking an overreaction which subsequently becomes independent from bleeding, as postulated in other studies.…”

Section: Discussionsupporting

confidence: 62%

Clinical, instrumental, serological and histological findings suggest that hemophilia B may be less severe than hemophilia A

et al. 2015

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Section: Discussionsupporting

confidence: 62%

Clinical, instrumental, serological and histological findings suggest that hemophilia B may be less severe than hemophilia A

et al. 2015

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“…These synovial changes indirectly damage and destroy cartilage, but more recent data have shown that cartilage may be directly and independently affected by haemarthrosis. Biochemical markers of chondrocyte damage, such as impaired proteoglycan synthesis, may be seen after relatively short exposure to blood [3,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, physical factors such as joint loading may act synergistically to cause long-term joint damage after joint bleeds [7]. In vitro studies demonstrate that these changes occur in a doseand time-dependent manner, and that a duration of joint exposure to blood as short as 2 days may be sufficient to initiate long-term changes [5]. These issues may be important in guiding treatment for haemarthrosis.…”

Section: Introductionmentioning

confidence: 99%

Management of acute haemarthrosis in haemophilia A without inhibitors: literature review, European survey and recommendations

Hermans

Moerloose

Fischer³

et al. 2011

Haemophilia

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Summary. Acute haemarthrosis is a frequent type of bleeding in individuals with haemophilia. Delayed and/or inadequate treatment can trigger a series of pathological changes within the joint, leading to a painful and disabling arthropathy. The early management of intra‐articular bleeding has the potential to prevent chronic joint disease and may include a combination of factor replacement, rest, ice, rehabilitation and, in certain cases, joint aspiration. Little data are, however, available regarding the optimal management of acute haemarthrosis, especially with respect to replacement therapy and the use of adjunctive therapies (aspiration, avoidance of weight bearing and immobilization, as well as the use of anti‐inflammatory medication and embolization). To provide more insight into the management of acute haemarthrosis in patients with haemophilia, a literature review was conducted. Concomitantly, current management was surveyed in 26 European haemophilia comprehensive care centres representing 15 different countries. The review highlights the need for future robust studies to better define the appropriate replacement therapy and the role of adjunctive therapies such as aspiration. The survey reveals much heterogeneity in the management of acute haemarthrosis across the EU. Within the constraints discussed, treatment recommendations are presented that reflect the literature, current practice and the clinical experience of the European Haemophilia Therapy Standardisation Board (EHTSB).

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“…Hemophilia is characterized by frequent intra-articular and intramuscular bleeding episodes, causing damage to joint [1,2] and soft tissue, therefore, predisposing to arthropathy and musculoskeletal dysfunction [3,4]. Treatment of hemophilia with factor replacement aims to minimize structural damage to joints and maximize patients' functional independence and quality of life [5].…”

Section: Introductionmentioning

confidence: 99%

Functional independence score in hemophilia: A cross‐sectional study assessment of Mexican children

Tlacuilo‐Parra¹,

Villela-Rodriguez²,

Garibaldi-Covarrubias³

et al. 2009

Pediatric Blood & Cancer

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BackgroundThe Functional Independence Score in Hemophilia (FISH) is a performance‐based assessment tool used to measure the patients functional ability so far only used in patients with severe hemophilia. Its aim is to determine if FISH is useful in patients with mild and moderate disease.ProcedureIn a cross‐sectional study 90 children 60 hemophilic and 30 sex‐, race‐, and age‐matched healthy males were assessed. Patients between 5 and 16 years of age were selected each patient was evaluated in seven activities under three categories: self‐care (grooming and eating, bathing, and dressing), transfers (chair and squat), and locomotion (walking and step climbing). Each activity was graded from 1 to 4 according to the amount of assistance required to perform the activity with total scores ranging from 7 to 28.ResultsAs a whole, the mean age of the patients was 10.0 ± 3.4 years with a mean FISH of 25.8 ± 3.6 (range 15–28). There were no differences in the FISH between healthy males and patients with mild hemophilia; however, the score was significantly higher in patients with mild hemophilia (28 ± 0) than patients with moderate (26.2 ± 2.5; P = 0.004) or severe hemophilia (24.0 ± 4.7; P = 0.0006). The most affected activities were squatting, walking, and step climbing.ConclusionsA significant decrease in functional ability was demonstrated according to the severity of hemophilia, especially for those activities involving weight‐bearing demands like locomotion and step climbing. Of seven activities evaluated, changes were observed in the group with moderate and severe hemophilia, but no changes detected in patients with mild disease. Pediatr Blood Cancer 2010;54:394–397. © 2009 Wiley‐Liss, Inc.

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Exposure of human cartilage tissue to low concentrations of blood for a short period of time leads to prolonged cartilage damage: An in vitro study

Cited by 116 publications

References 37 publications

Clinical, instrumental, serological and histological findings suggest that hemophilia B may be less severe than hemophilia A

Clinical, instrumental, serological and histological findings suggest that hemophilia B may be less severe than hemophilia A

Management of acute haemarthrosis in haemophilia A without inhibitors: literature review, European survey and recommendations

Functional independence score in hemophilia: A cross‐sectional study assessment of Mexican children

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