Exposure of mother rats to chronic unpredictable stress before pregnancy alters the metabolism of gamma-aminobutyric acid and glutamate in the right hippocampus of offspring in early adolescence in a sexually dimorphic manner

Huang, Yuejun; Shen, Zhiwei; Hu, Liu; Xia, Fang; Li, Yuewa; Zhuang, Jing-wen; Chen, Peishan; Huang, Qingjun

doi:10.1016/j.psychres.2016.10.005

Cited by 18 publications

(9 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased levels of GABA have been reported in the hippocampus of CMS-offspring exposed to an acute stressor (Huang et al, 2016). Ex vivo 1 H-MRS studies support elevated GABA levels following CMS and restraint stress with increases observed in the anterior cingulate and prefrontal cortex, respectively (Perrine et al, 2014; Drouet et al, 2015) suggesting that altered inhibitory neurotransmission may be involved in the pathophysiology of CMS.…”

Section: Mri In Animal Models Of Depressionmentioning

confidence: 99%

“…Exposing the offspring of dams subjected to CMS to an acute stressor in adolescence (a single forced swim test) decreased glutamate MR signal in the right hippocampus (Huang et al, 2016). Similarly, chronic exposure to the FST has been reported to decrease the glutamate signal in both the prefrontal cortex and hippocampus in rats (Li et al, 2008).…”

Section: Mri In Animal Models Of Depressionmentioning

confidence: 99%

“…These conflicting changes in hippocampal glutamate may be due to the type of stressor used (acute compared to chronic) or regional differences within the hippocampus. Delgado et al positioned a 2 mm 3 voxel in the ventral part of the left hippocampus whereas Huang et al (2016) positioned their 2.5 × 4 × 4 mm voxel in the dorsal area of the right hippocampus. Similar decreases in dorsal hippocampal glutamate have been reported in rats bred for learned helplessness (cLH) compared to Sprague-Dawley controls and also following CMS (Hemanth Kumar et al, 2012; Schulz et al, 2013).…”

Section: Mri In Animal Models Of Depressionmentioning

confidence: 99%

See 2 more Smart Citations

Recent Advances in Translational Magnetic Resonance Imaging in Animal Models of Stress and Depression

McIntosh

Gormley

Tozzi

et al. 2017

Front. Cell. Neurosci.

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) is a valuable translational tool that can be used to investigate alterations in brain structure and function in both patients and animal models of disease. Regional changes in brain structure, functional connectivity, and metabolite concentrations have been reported in depressed patients, giving insight into the networks and brain regions involved, however preclinical models are less well characterized. The development of more effective treatments depends upon animal models that best translate to the human condition and animal models may be exploited to assess the molecular and cellular alterations that accompany neuroimaging changes. Recent advances in preclinical imaging have facilitated significant developments within the field, particularly relating to high resolution structural imaging and resting-state functional imaging which are emerging techniques in clinical research. This review aims to bring together the current literature on preclinical neuroimaging in animal models of stress and depression, highlighting promising avenues of research toward understanding the pathological basis of this hugely prevalent disorder.

show abstract

Section: Mri In Animal Models Of Depressionmentioning

confidence: 99%

Section: Mri In Animal Models Of Depressionmentioning

confidence: 99%

Section: Mri In Animal Models Of Depressionmentioning

confidence: 99%

See 1 more Smart Citation

Recent Advances in Translational Magnetic Resonance Imaging in Animal Models of Stress and Depression

McIntosh

Gormley

Tozzi

et al. 2017

Front. Cell. Neurosci.

View full text Add to dashboard Cite

show abstract

“…These early neurochemical changes might alter the entire programing of the hypothalamic– pituitary–adrenal (HPA) axis function. Furthermore, alterations in HPA axis activity could be related to functional changes in serotonin activity and serotonin transporter expression in the hippocampus and hypothalamus of fetuses in a sexually dimorphic way (Huang et al , 2012 , 2016 ). Pre-gestational stress also appears to cause long-lasting changes in hippocampal mechanisms in the offspring rats (Huang et al , 2013 ; Gemmel et al , 2017 ).…”

Section: Models Of Early Life Stressmentioning

confidence: 99%

“…Offspring of affected mothers showed decreased coping ability in the forced swimming and deficits in sibling play behavior of juvenile offspring (Grundwald et al , 2016 ; Gemmel et al , 2017 ). All these neurochemical, neurobehavioral changes could result in the decreased ability of an organism to respond and adapt to stressful stimuli later in adolescent or in adulthood (Huang et al , 2016 ). At the same time, perinatal antidepressant exposure had an enduring effect on the HPA system and the central serotonergic system by increasing serotonin and CBG levels in the hippocampus (Gemmel et al , 2017 ).…”

Section: Models Of Early Life Stressmentioning

confidence: 99%

Animal models of maternal depression for monitoring neurodevelopmental changes occurring in dams and offspring

Bögi

Belovičová

Csatlósová

et al. 2017

Interdisciplinary Toxicology

View full text Add to dashboard Cite

Depression is one of the most prevalent and life-threatening forms of mental illness affecting about 20% of the population. Depressive disorder as a biochemical phenomenon, was first recognized in the mid-20th century of research, however the etiology of this disease is still not well understood. Although the need to investigate depressive disorders has emerged from the needs of clinical practice, there are many preclinical studies, which brought new insights into this field of research. During experimental work it was crucial to develop appropriate animal models, where the neurohumoral mechanism was similar to humans. In the past decades, several animal models of maternal depression have been developed. We describe the three most popular rodent models of maternal depression which are based on 1. stress prior to gestation, 2. prenatal stress and 3. early life stress. The above-mentioned animal models appear to fulfill many criteria for a relevant animal model of depression; they alter the regulation of the HPA, induce signs of depression-like behavior and several antidepressant treatments can reverse the state induced by maternal stress. Although, they are not able to model all aspects of maternal depression, they are useful models for monitoring neurodevelopmental changes occurring in dams and offspring.

show abstract

Association of Prenatal Maternal Psychological Distress With Fetal Brain Growth, Metabolism, and Cortical Maturation

et al. 2020

View full text Add to dashboard Cite

IMPORTANCE Prenatal maternal stress is increasingly associated with adverse outcomes in pregnant women and their offspring. However, the association between maternal stress and human fetal brain growth and metabolism is unknown. OBJECTIVE To identify the association between prenatal maternal psychological distress and fetal brain growth, cortical maturation, and biochemical development using advanced 3-dimensional volumetric magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H-MRS).

show abstract

Exposure of mother rats to chronic unpredictable stress before pregnancy alters the metabolism of gamma-aminobutyric acid and glutamate in the right hippocampus of offspring in early adolescence in a sexually dimorphic manner

Cited by 18 publications

References 64 publications

Recent Advances in Translational Magnetic Resonance Imaging in Animal Models of Stress and Depression

Recent Advances in Translational Magnetic Resonance Imaging in Animal Models of Stress and Depression

Animal models of maternal depression for monitoring neurodevelopmental changes occurring in dams and offspring

Association of Prenatal Maternal Psychological Distress With Fetal Brain Growth, Metabolism, and Cortical Maturation

Contact Info

Product

Resources

About