Exposure of nano- and ultrafine Ni particles to synthetic biological solutions: predicting fate-related dissolution and accumulation

Abzhanova, Diana; Godymchuk, Anna; Gusev, Alexander; Кузнецов, Денис

doi:10.1515/ejnm-2016-0021

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…In contrary, platinum as a noble metal is ‘not soluble’ in water (Artelt et al 1999). Furthermore, Abzhanova et al (2016) reported high dissolution rates for nickel particles in biological simulants. After 2 h of exposure to artificial saliva or lysosomal liquid, dissolution rates of up to 30 respectively 60% were recorded.…”

Section: Introductionmentioning

confidence: 99%

Biokinetics of nanomaterials: The role of biopersistence

et al. 2017

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Nanotechnology risk management strategies and environmental regulations continue to rely on hazard and exposure assessment protocols developed for bulk materials, including larger size particles, while commercial application of nanomaterials (NMs) increases. In order to support and corroborate risk assessment of NMs for workers, consumers, and the environment it is crucial to establish the impact of biopersistence of NMs at realistic doses. In the future, such data will allow a more refined future categorization of NMs. Despite many experiments on NM characterization and numerous in vitro and in vivo studies, several questions remain unanswered including the influence of biopersistence on the toxicity of NMs. It is unclear which criteria to apply to characterize a NM as biopersistent. Detection and quantification of NMs, especially determination of their state, i.e., dissolution, aggregation, and agglomeration within biological matrices and other environments are still challenging tasks; moreover mechanisms of nanoparticle (NP) translocation and persistence remain critical gaps. This review summarizes the current understanding of NM biokinetics focusing on determinants of biopersistence. Thorough particle characterization in different exposure scenarios and biological matrices requires use of suitable analytical methods and is a prerequisite to understand biopersistence and for the development of appropriate dosimetry. Analytical tools that potentially can facilitate elucidation of key NM characteristics, such as ion beam microscopy (IBM) and time-of-flight secondary ion mass spectrometry (ToF-SIMS), are discussed in relation to their potential to advance the understanding of biopersistent NM kinetics. We conclude that a major requirement for future nanosafety research is the development and application of analytical tools to characterize NPs in different exposure scenarios and biological matrices.

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Section: Introductionmentioning

confidence: 99%

Biokinetics of nanomaterials: The role of biopersistence

et al. 2017

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Agglomeration and dissolution of iron oxide nanoparticles in simplest biological media

et al. 2022

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<abstract> Despite high medical and biological potential, the penetration of iron oxide nanoparticles (NPs) into a human body can cause their dissolution with subsequent accumulation of highly toxic iron compounds. The paper describes the agglomeration and dissolution behavior of differently sized α-Fe2O3 NPs in the simplest biological solutions. The average sizes of the initial NPs according to the BET analysis are 12, 32, and 115 nm. Within 30–60 min exposure, the particle size and concentration of iron released into the solutions increases in the suspensions, accompanied by an intensive change of NPs surface charge. After an hour of exposure, the colloidal properties do not change significantly, although the dissolution degree ambiguously fluctuates. It has been shown that the agglomeration of the particles in the simplest pulmonary fluid is lower than in the simplest sweat fluid, compared to the dissolution degree, which is much higher in the pulmonary fluid than in the sweat. The colloidal stability of suspensions reduces with a decrease of NPs' size, e.g., the average size of particles is 315,289, and 248 nm, while zeta potential is 2, 9, and 17 mV, respectively for 12, 32, and 115 nm NPs in 3-hour suspensions. It has been found that 24 h dissolution degree of α-Fe2O3 NPs reaches 2.3% and 0.4%, respectively, in the simplest pulmonary and sweat fluids. The mechanism of dissolution of hematite NPs in the slightly acidic and acidic mediums is proposed. </abstract>

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Exposure of nano- and ultrafine Ni particles to synthetic biological solutions: predicting fate-related dissolution and accumulation

Cited by 2 publications

References 26 publications

Biokinetics of nanomaterials: The role of biopersistence

Biokinetics of nanomaterials: The role of biopersistence

Agglomeration and dissolution of iron oxide nanoparticles in simplest biological media

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