Exposure of young rats to high estrogen doses leads to degeneration of elongated spermatids

Pinto, Maria Etelvina; Vilamaior, Patrícia Simone Leite; Taboga, Sebastião Roberto; Góes, Rejane Maira

doi:10.1016/j.tice.2007.09.002

Cited by 12 publications

(7 citation statements)

References 33 publications

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“…Furthermore, testosterone, after its conversion to estradiol by aromatase, maintains Sertoli’s cells functions. Consequently, low testosterone levels and alteration of estradiol catabolism result in high levels of estradiol, which compromise sperm production as demonstrated in young rats treated with high doses of estrogens [9].…”

Section: Mechanisms Of Bpa As Reproductive Toxicitymentioning

confidence: 99%

“Bisphenol a: an emerging threat to male fertility”

Cariati

D’Uonno

Borrillo

et al. 2019

Reprod Biol Endocrinol

133

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BackgroundAmong the factors causing male infertility, one of the most debated is the exposure to environmental contaminants. Recently, the chemical compound Bisphenol A (BPA) has drawn attention from the reproductive science community, due to its ubiquitous presence in day-to-day life. Its toxic action appears to mainly affect the male reproductive system, directly impacting male fertility.MainThe purpose of this review is to investigate current research data on BPA, providing an overview of the findings obtained from studies in animal and human models, as well as on its supposed mechanisms of action.ConclusionA clear understanding of BPA action mechanisms, as well as the presumed risks deriving from its exposure, is becoming crucial to preserve male fertility. The development and validation of methodologies to detect BPA toxic effects on reproductive organs can provide greater awareness of the potential threat that this chemical represents.

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Section: Mechanisms Of Bpa As Reproductive Toxicitymentioning

confidence: 99%

“Bisphenol a: an emerging threat to male fertility”

Cariati

D’Uonno

Borrillo

et al. 2019

Reprod Biol Endocrinol

133

View full text Add to dashboard Cite

show abstract

“…Such exposure interferes with development of elongated SPT, as BPA likely acts as estrogenic chemical [19]. Indeed, estrogens lead to degeneration of elongated SPT in young rats in vivo exposed to high doses [36], while in mouse they modulate chromatin remodeling of SPT during spermiogenesis [37,38]. In particular, 17β-Estradiol is reported to facilitate histone-protamine exchange in mouse SPT by promoting histone displacement [5].…”

Section: International Journal Of Endocrinologymentioning

confidence: 99%

Fetal-Perinatal Exposure to Bisphenol-A Affects Quality of Spermatozoa in Adulthood Mouse

Chioccarelli

Manfrevola

Migliaccio

et al. 2020

International Journal of Endocrinology

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Bisphenol-A (BPA) is considered an endocrine disruptor with estrogenic activity. It is described as an environment-polluting industrial chemical whose adverse effects on the male reproductive system depend on the period of exposure (i.e., fetal, prepubertal, or adult life). We exposed male mice to BPA during the fetal-perinatal period (from 10 days post coitum to 31 days post partum) and investigated the impact of this early-life exposure on gamete health in adulthood animals at 78 days of age. Both in control and BPA-exposed mice, viability and motility of spermatozoa, as well as sperm motility acquisition and chromatin condensation of spermatozoa, have been evaluated. Results reveal harmful effect of BPA on viability and motility of sperm cells as well as on chromatin condensation status during epididymal maturation of spermatozoa. In particular, BPA exposure interferes with biochemical mechanism useful to stabilize sperm chromatin condensation, as it interferes with oxidation of thiol groups associated to chromatin.

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“…Low fertility rates can be attributed to many causes, some being hormonal imbalances (Pinto et al ., ) and testosterone treatment has been shown to improve fertility rates in subjects with idiopathic fertility in a double‐blind study (Gregoriou et al ., ). The effect of TA in reducing the inhibitory effects of oestrogen on spermatogenic cells were demonstrated where the spermatogenic cell counts and the percentage of motile sperms in the TA‐treated group and the El combined with estradiol‐treated group increased significantly compared with the estradiol‐treated group.…”

Section: Effect On Reproductive Systemmentioning

confidence: 99%

Phytoandrogenic properties ofEurycoma longifoliaas natural alternative to testosterone replacement therapy

George

Henkel

2014

Andrologia

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The testosterone deficiency syndrome (TDS) is characterised by numerous symptoms, including low libido, increased fat mass, fatigue, erectile dysfunction or osteoporosis, and up to 80% of men will experience some kind of ageing males' symptoms. This is caused by the age-depending decline in serum testosterone levels with concentrations being about 40-50% lower in men older than 60 years compared with young men. This significant decline in testosterone levels is further closely linked with medical conditions such as obesity, metabolic syndrome, diabetes or hypertension. The conventional way of treating TDS is the testosterone replacement therapy (TRT), for which preparations are on the market. Apart from the beneficial effects of TRT, significant adverse side effects have been described, and prostate cancer (PCa) as absolute contraindication is debated. Eurycoma longifolia (Tongkat Ali; TA) is natural alternative to TRT and has been shown to restore serum testosterone levels, thus significantly improving sexual health. This includes significant positive effects on bone health and physical condition of patients. In addition, a significant antihyperglycaemic effect and cytotoxicity against PCas cells has been shown. Thus far, at therapeutic concentrations, no significant side effects of the treatment were obvious. Therefore, TA might be a safe alternative to TRT.

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Exposure of young rats to high estrogen doses leads to degeneration of elongated spermatids

Cited by 12 publications

References 33 publications

“Bisphenol a: an emerging threat to male fertility”

“Bisphenol a: an emerging threat to male fertility”

Fetal-Perinatal Exposure to Bisphenol-A Affects Quality of Spermatozoa in Adulthood Mouse

Phytoandrogenic properties ofEurycoma longifoliaas natural alternative to testosterone replacement therapy

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